Granzyme K Products

Description

The granzyme family of proteins belong to the larger peptidase S1 family. Granzyme A and granzyme B are serine proteases that facilitate apoptotic signaling in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Within the granules of activated CTLs, granzyme A and B are processed and converted to their active forms by the lysosomal cysteine protease cathepsin C. Once cleaved, these active proteases target distinct substrates for proteolysis and, thereby, mediate apoptosis through two different pathways. Granzyme H localizes to cytoplasmic granules of cytolytic T lymphocytes and is important for target cell lysis in cell-mediated immune responses. Granzyme K (GMZK), also designated granzyme-3 or NK-tryptase-2 (NK-TRYP-2), contains one peptidase S1 domain. Granzyme K is a serine protease localizing to the granules of natural killer cells and cytotoxic T lymphocytes. It is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.

Bioinformatics

Entrez	14945 Mouse 29165 Rat 3003 Human
Uniprot	AAH35802 Human NM_002104 Human NP_002095 Human NP_002095.1 Human P49863 Human
Product By Gene ID	3003
Alternate Names	EC 3.4.21 EC 3.4.21.- EC 3.4.21.4 Fragmentin-3 fragmentin-3 granzyme 3 granzyme K (granzyme 3; tryptase II) granzyme K (serine protease, granzyme 3; tryptase II) granzyme K Granzyme-3 NK-Tryp-2 NK-tryptase-2 PRSS TRYP2granzyme-3 tryptase II