Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Pm
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Rat
Human
Human
|
| Product By Gene ID |
2729 |
| Alternate Names |
- EC 6.3.2.2
- gamma-ECS
- Gamma-ECS
- Gamma-glutamylcysteine synthetase
- GCS heavy chain
- GCS
- GLCL
- GLCLCGCL
- glutamate--cysteine ligase catalytic subunit
- glutamate-cysteine ligase, catalytic subunit
|
