Doublecortin Products

Description

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The encoded protein contains two doublecortin domains, which bind microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene are a cause of X-linked lissencephaly. Multiple transcript variants encoding at least three different isoforms have been found for this gene.

Bioinformatics

Entrez	13193 Mouse 1641 Human 84394 Rat
Uniprot	AAH27925 Human NM_178151 Human NM_178152 Human NP_000546 Human NP_000546.2 Human NP_000546.2 Human NP_001182482.1 Human NP_835364 Human NP_835364.1 Human NP_835364.1 Human NP_835365.1 Human NP_835366 Human O43602 Human
Product By Gene ID	1641
Alternate Names	doublecortin Doublin FLJ51296 Lissencephalin-X Lis-X X-linked (doublecortin)

Research Areas for Doublecortin

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Phospho-Specific
Signal Transduction