DORFIN Products

Description

Dorfin is an E3 ubiquitin ligase which mediates ubiquitination of cellular proteins. Dorfin contains two RING-finger motifs and an IBR (in between RING fingers) motif. Dorfin interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. Dorfin is of interest in Parkinson's Disease, as it binds and ubiquitylates synphilin 1 (SNCAIP - interacts with alpha synuclein) in neurons. Furthermore, Dorfin expression is increased in Lewy bodies, the characteristic neuronal inclusions in Parkinson's diseased brains. In normal subjects, Dorfin is widely expressed at low levels with higher levels found in the heart and is ubiquitously expressed in the central nervous system. Alternatively spliced transcript variants encoding the same protein have been reported.

Bioinformatics

Entrez	25897 Human
Uniprot	NM_015435 Human NP_056250 Human NP_056250.3 Human NP_904355 Human Q9NV58 Human
Product By Gene ID	25897
Alternate Names	DKFZp566B1346 DORFIN Dorfin dorfin Double ring-finger protein E3 ubiquitin-protein ligase RNF19A EC 6.3.2 EC 6.3.2.- p38 protein p38 interacting with transcription factor Sp1 RING finger protein 19 isoform ring finger protein 19 ring finger protein 19Ap38 protein ring-IBR-ring domain containing protein Dorfin RNF19

Research Areas for DORFIN

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