Cadherin-11 Products

Description

Cadherin-11 is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. Cadherin-11 is expressed in osteoblasts and the brain as well as other tissues.Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues.

Bioinformatics

Entrez	1009 Human 12552 Mouse 84407 Rat
Uniprot	NM_001797 Human NP_001788 Human NP_001788.2 Human P55287 Human
Product By Gene ID	1009
Alternate Names	CAD11OSF-4 cadherin 11, type 2, OB-cadherin (osteoblast) cadherin-11 CDHOB OB OB-cadherin Osteoblast cadherin

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