Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Goat Polyclonal
Species: Hu, Mu, Rt, Bv, Ch, RM
Applications: WB, ICC/IF, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growingsubclass of the Bcl-2 family. A novel BH3 domaincontaining protein was recently identified and designated Bnip3L, Bnip3a, and Nix (for Nip3-like protein X) (Matsushima, M. et al.; Yasuda, M. et al.; Chen, G, et al.).Bnip3L/Bnip3a/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Over expression of Bnip3L induces apoptosis (Yasuda, M. et al.; Chen, G, et al.). Bnip3L interacts withand overcomes suppresses by Bcl-2 and Bcl-xL. Bnip3Lis localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues (Matsushima, M. et al.; Yasuda, M. et al.). Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.
Bioinformatics
| Entrez |
Mouse
Bovine
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
665 |
| Alternate Names |
- Adenovirus E1B19K-binding protein B5
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
- BCL2/adenovirus E1B 19-kd protein-interacting protein 3a
- BCL2/adenovirus E1B 19kDa interacting protein 3-like
- BNIP3a
- BNIP3A
- BNIP3H
- NIP3L
- NIP3-like protein X
- Nix
- NIXBCL2/adenovirus E1B 19kD-interacting protein 3-like
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