Activin RIIB Products

Description

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq]

Bioinformatics

Entrez	93 Human
Uniprot	AAH96245.1 Human CAA54671 Human NM_001106 Human NP_001097 Human Q13705 Human Q4VAU9 Human
Product By Gene ID	93
Alternate Names	activin A receptor, type IIB Activin receptor type IIB activin receptor type-2B ACTRIIB ACTR-IIB ActR-IIB EC 2.7.11 EC 2.7.11.30 MGC116908

Research Areas for Activin RIIB

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Protein Kinase