Species: Hu
Applications: Flow, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Po
Applications: WB, ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Mu, Po
Applications: WB, Flow, IHC, CyTOF-ready, ICC/IF
Host: Sheep Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: All-NA
Applications: Func
Species: Hu
Applications: WB
Species: Hu
Applications: Enzyme Activity
Species: Hu
Applications: Bioactivity, Enzyme Activity
Species: Hu
Applications: Binding Activity, Enzyme Activity
Description
Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.[supplied by OMIM]
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
4907 |
| Alternate Names |
- 5' nucleotidase (CD73)
- 5'-NT
- 5'-nucleotidase, ecto (CD73)
- CD73 antigen
- CD73
- E5NT
- EC 3.1.3.5
- Ecto-5'-nucleotidase
- ecto-5'-nucleotidase
- eN
- eNT
- NT
- NT55'-nucleotidase
- NTE
- Purine 5-Prime-Nucleotidase
|
Research Areas for 5'-Nucleotidase/CD73
Find related products by research area and learn more about each of the different research areas below.
Lipid and Metabolism
![Flow Cytometry 5'-Nucleotidase/CD73 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/5'-Nucleotidase_AF4488_Flow_Cytometry_8251.jpg)
![Binding Activity 5'-Nucleotidase/CD73 [Biotin]](http://images.novusbio.com/fullsize2/avi5795_recombinant-human-5-nucleotidase-cd73-his-tag-avi-tag-cf-binding-activity-65202191656.jpg)
![Binding Activity 5'-Nucleotidase/CD73 [Biotin]](http://images.novusbio.com/fullsize/avi11377_recombinant-human-5-nucleotidase-cd73-fc-avi-tag-cf-binding-activity-1492023101649..jpg)
![Flow Cytometry 5'-Nucleotidase/CD73 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/5Nucleotidase_AF4488_Flow_Cytometry_15682.jpg)
![Immunohistochemistry 5'-Nucleotidase/CD73 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/5'-Nucleotidase_AF4488_Immunohistochemistry_11454.jpg)
![Immunocytochemistry 5'-Nucleotidase/CD73 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/5Nucleotidase_AF4488_Immunocytochemistry_15883.jpg)
![Immunocytochemistry/ Immunofluorescence 5'-Nucleotidase/CD73 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af4488_mouse-porcine-5-nucleotidase-cd73-affinity-purified-pab-4120241049424.jpg)
![SDS-PAGE 5'-Nucleotidase/CD73 [Biotin]](http://images.novusbio.com/fullsize2/avi5795_recombinant-human-5-nucleotidase-cd73-his-tag-avi-tag-cf-sds-page-24102022142429.jpg)