CENPF Products

Description

CENPF (Centromere protein F) is required for proper chromosome segregation in mitosis, and has a cell-cycle distribution that is both temporally regulated and diverse in terms of the structural component localization. Specifically, CENPF is a component of the nuclear matrix during the G2 phase of interphase. In late G2, it associates with the kinetochore and maintains this association through early anaphase. Here, CENPF is required for kinetochore function and appears to be the earliest member to interact with the centromere-kinetochore complex. It then localizes to the spindle midzone in late anaphase and to the intracellular bridge in telophase, where the protein is subsequently degraded. Given this diversity of function, CENPF is expected to play an important role in several mitotic events.

Bioinformatics

Entrez	1063 Human
Uniprot	AAA82889.1 Human AAA82935.1 Human AAA86889.1 Human
Product By Gene ID	1063
Alternate Names	AH antigen cell-cycle-dependent 350K nuclear protein CENF CENP-F kinetochore protein CENP-F centromere protein F (350/400kD, mitosin) centromere protein F centromere protein F, 350/400ka (mitosin) centromere protein F, 350/400kDa (mitosin) hcp-1 Kinetochore protein CENPF mitosin Mitosin PRO1779

Research Areas for CENPF

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Chromatin Research

Related CENPF Blog Posts

Check out the latest blog posts on CENPF.

CENPF Antibodies as Potential Cancer Markers Centromere protein F (CENPF), also named mitosin, is a large human protein of 3113 amino acid residues. Its expression and localization are cell cycle-dependent. The protein levels are low in G1 phase but elevated from S to early M phase. CENPF is a n...    Read more.

CENPF: At the Center-o'-mere Mitotic Division (Infographic) Centromere protein F (CENPF) also known as Mitosin, AH antigen, and kinetochore protein CENPF, is a protein that associates with the centromere-kinetochore complex. CENPF forms both a homodimer and a heterodimer. CENPF can be found in different cellul...    Read more.

Read more CENPF related blogs.