Membrane fusion is an essential step during the trafficking of endosomes and vesicles throughout the cell. Membrane fusion events are facilitated by multisubunit tethering complexes (MTC) including CORVET and HOPS. These complexes interact with Rab GTPases and SNARE proteins to promote the fusion of endosomes and lysosomes (1). In yeast VPS41 is a component of the HOPS complex that is needed for transport of endosomes and Golgi-derived vesicles to the vacuole. The choice between these two substrates is facilitated by the phosphorylation of VPS1 by Yck3 (2). Carbrera et al.
