Various studies have been performed tracking the involvement of p38 mitogen-activated protein kinase (MAPK) and caspase-3 antibodies in cobalt chloride (CoCl2) induced apoptosis in PC12 cells.
Studies have proven the usefulness of CoCl2 treatment to induce apoptosis in PC12 rat tumor cells. Treating these cells with CoCl2 leads to programmed cell death (apoptosis). Such cells provide a simple and useful model for the study of hypoxia-related neuronal disorders, as hypoxia involves a lack of oxygen.
