neurodegenerative

Parkinson's disease affects the nervous system which controls movement. Damage to the levels of dopamine in the brain impairs the ability to relay messages to parts of the body which control movement. While the exact cause of the disease is unknown, researchers are examining genetic causes linked to the LRRK2 gene and environmental factors.

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LC3B, also known as microtubule-associated protein 1 light chain 3 beta (MAP1LC3B), is an autophagy gene that contributes appreciably to protein degradation. Autophagy is a highly synchronized and dynamic catabolic degradation activity that plays an essential role in cellular maintenance, development, antigen presentation and cell death.