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Kif2a proteins

Kif2a and MT-Destabilization during Mitosis

Kif2a belongs to the Kinesin-13 microtubule depolymerase family that includes members Kif2a, Kif2b, and Kif2c. These proteins are capable of depolymerizing microtubules (MTs) at their ends. During mitotic cell division, Kif2a specifically localizes to centrosomes and is essential for chromosome organization at the metaphase plate, spindle dynamics and turnover, and bipolar mitotic spindle formation.