Dicer

Dicer is an RNaseIII-like enzyme capable of cleaving double-stranded RNA (dsRNA) into smaller 21-23 nt RNA fragments known as short interfering RNA (siRNAs). It targets the selective degradation of complementary RNAs in a posttranscriptional gene silencing (PTGS) manner and is key for cell differentiation and development. Unlike long-dsRNA-dependent PTGS which is limited to certain cell types, siRNA can act in a wide variety of cells.

Ago2, also called eIF2C2, antibody is one of 37 reagents targeted to the Argonaute protein family that we at Novus Biologicals have in our antibody catalogue. Argonaute proteins are encoded by genes which play an important role in regulating the control of gene expression by miRNA (microRNA). Recently, a new antibody study showed that the role of Ago2 may be to help generate production of miRNA, rather than simply moderate its function.