Also known as PROM1 and AC133, this gene is located on chromosome 4p15 and encodes CD133, a 120kDa pentaspan transmembrane glycoprotein (5-TM) and presents multiple spliced variants. Prominin-1 (CD133) was the first protein identified as "Prominin"; originated from the Latin word "Prominere" meaning to protrude and was initially detected on CD34 bright hematopoietic stem cells using a monoclonal antibody (mAb) raised against human CD34+cells.
