AIF Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Apoptosis-inducing factor (AIF, also known as programmed cell death protein 8) is a 58 kDa member of the FAD-dependent oxidoreductase family of molecules. It is ubiquitously expressed and found in the mitochondrial intermembrane space. AIF likely acts as a mitochondrial antioxidant providing protection via NADH oxidase activity. Upon release from the mitochondria, AIF passes into the nucleus where it initiates apoptosis. Human AIF precursor is 67 kDa in size and 613 amino acids (aa) in length and contains a cleavable N-terminal 102 aa mitochondrial localization sequence, followed by a spacer region (aa 103‑129) and an oxidoreductase domain (aa 130‑613) that possesses an NLS (aa 446‑451). Over aa 121‑613, human AIF shares 95% aa identity with mouse AIF.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: ICC, IHC, IHC-Fr, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using AF1457	Applications	Species
H Nakajima, M Itakura, T Kubo, A Kaneshige, N Harada, T Izawa, YT Azuma, M Kuwamura, R Yamaji, T Takeuchi Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction during Oxidative Stress-induced Cell Death J. Biol. Chem, 2017-02-06;292(11):4727-4742. 2017-02-06 [PMID: 28167533] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Delivery of a survivin promoter-driven antisense survivin-expressing plasmid DNA as a cancer therapeutic: a proof-of-concept study Onco Targets Ther, 2016-05-03;9(0):2601-13. 2016-05-03 [PMID: 27217778] (Western Blot, Human)	Western Blot	Human
L Admoni-Eli, I Nakdimon, A Shteinfer, T Prezma, T Arif, N Arbel, A Melkov, O Zelichov, I Levi, V Shoshan-Ba Novel Biomarker Proteins in Chronic Lymphocytic Leukemia: Impact on Diagnosis, Prognosis and Treatment PLoS ONE, 2016-04-14;11(4):e0148500. 2016-04-14 [PMID: 27078856] (Western Blot, Human)	Western Blot	Human
Hwang J, Hsu C, Yu W, Liu T, Yang W Diet-induced obesity exacerbates auditory degeneration via hypoxia, inflammation, and apoptosis signaling pathways in CD/1 mice. PLoS ONE, 2013-04-26;8(4):e60730. 2013-04-26 [PMID: 23637762] (IHC, Mouse)	IHC	Mouse
Hisatomi T, Nakao S, Murakami Y, Noda K, Nakazawa T, Notomi S, Connolly E, She H, Almulki L, Ito Y, Vavvas DG, Ishibashi T, Miller JW The regulatory roles of apoptosis-inducing factor in the formation and regression processes of ocular neovascularization. Am. J. Pathol., 2012-05-19;181(1):53-61. 2012-05-19 [PMID: 22613025] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Notomi S, Hisatomi T, Kanemaru T, Takeda A, Ikeda Y, Enaida H, Kroemer G, Ishibashi T Critical involvement of extracellular ATP acting on P2RX7 purinergic receptors in photoreceptor cell death. Am. J. Pathol., 2011-10-08;179(6):2798-809. 2011-10-08 [PMID: 21983632] (ICC, Mouse)	ICC	Mouse

Array AF1457

• AIF Antibodies
• AIF ELISA Kit
• AIF Lysates
• AIF Proteins