OS9 Antibody

OS9 (protein OS-9 or amplified in osteosarcoma 9) is a lectin/glycoprotein that functions in ER quality control and ER-associated degradation (ERAD pathway) of newly synthesized proteins. TRPV4 is its major target and OS9 also interact with GRP94, DERL2, HSP90B1, CREB3, ERLEC1, HSPA5 etc., forms a part of HRD1 ubiquitin ligase complex (SYVN1/HRD1 and SEL1L) which is involved in retrotranslocation of misfolded proteins from ER to cytosol for ubiquitin dependent degradation. OS9 is essential for recognizition of terminally misfolded non-glycosylated proteins or improperly folded glycoproteins, binding with them for their retention in ER, and transferring them to ubiquitination machinery for degradation. Moreover, it has also been shown to specifically protect some proteins from degradation process before maturation, ensuring their biological functionality. Because OS9 is implicated in protein quality control, it is closely related to ER stress, and gets up-regulated in response to ER stress. Recently, it has been shown to highly express in adipocytes wherein it regulated lipid storage, and its overexpression is also observed in sarcomas especially in osteosarcoma OSA-CL and rhabdomyosarcoma RH30 cell lines.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: KD, WB.

Showing Publications 1 - 5 of 5.

Publications using BC100-520	Applications	Species
Sun L, Xu C, Chen G et al. A Novel Role of OS-9 in the Maintenance of Intestinal Barrier Function from Hypoxia-induced Injury via p38-dependent Pathway. Int. J. Biol. Sci. 2015-05-22 [PMID: 25999789] (WB, Human)	WB	Human
Dougan SK, Hu CC, Paquet ME et al. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes Mol Cell Biol 2011-03-01 [PMID: 21220515] (WB, Mouse)	WB	Mouse
Fasana E, Fregno I, Galli C, Molinari M FAM134B regulates ER-to-lysosome-associated degradation of misfolded proteins upon pharmacologic or genetic inactivation of ER-associated degradation bioRxiv 2023-11-28 (WB, KD, Mouse)	WB, KD	Mouse
Bernasconi R, Galli C, Noack J et al. Role of the SEL1L:LC3-I Complex as an ERAD Tuning Receptor in the Mammalian ER. Mol Cell. 2012-05-23 [PMID: 22633958] (WB, Human)	WB	Human
Brockmeier U, Platzek C, Schneider K et al. The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. PLoS One. 2011-04-29 [PMID: 21559462] (WB, Human)	WB	Human

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Riccardo Bernasconi	WB		07/04/2012	View Summary Application Western Blot

Array BC100-520

• OS9 Antibodies
• OS9 Lysates
• OS9 Proteins