Synphilin-1 Products

Description

Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shares a high level of identity with its human counterpart, particularly in regions containing ankyrin-like motifs and the coiled-coil domain. Expression pattern of synphilin-1 in tissues is similar in both mouse and human. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and also Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1.

Bioinformatics

Entrez	9627 Human
Uniprot	AAH94759.1 Human NP_005451 Human Q6L986 Human Q9Y6H5 Human
Product By Gene ID	9627
Alternate Names	Alpha-synuclein-interacting protein MGC39814 Sph1 synphilin-1 synuclein, alpha interacting protein SYPH1

Research Areas for Synphilin-1

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Neuroscience