This antibody was developed against Recombinant Protein corresponding to amino acids: VEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTMIDAVKIYGKTKEQF
Predicted Species
Rat (98%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
UBR4
Purity
Immunogen affinity purified
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Mouse reactivity reported in scientific literature (PMID: 25084275).
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for UBR4 Antibody
600 kDa retinoblastoma protein-associated factor
EC 6.3.2
EC 6.3.2.-
KIAA0462E3 ubiquitin-protein ligase UBR4
KIAA1307zinc finger, UBR1 type 1
N-recognin-4
p600
RBAF600FLJ41863
Retinoblastoma-associated factor of 600 kDa
ubiquitin protein ligase E3 component n-recognin 4
Zinc finger UBR1-type protein 1
ZUBR1retinoblastoma-associated factor 600-like protein
Background
p600 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, p600 forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Additionally p600 regulates integrin-mediated signaling and may play a role in activation of FAK in response to cell-matrix interactions.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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