Transglutaminase 4/TGM4 Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TGM4 (Transglutaminase 4; also TGP and Prostate-specific transglutaminase) is a 77 kDa member of the papain-like family of transglutaminases. It is expressed by various tumor cell lines plus prostatic epithelium, and may participate in semen protein modification. TGM4, like other TGMs, can apparently mediate transamidation, plus esterification reactions. Human TGM4 is 684 amino acids (aa) in length. Although it does not contain a signal sequence, based on rodent, it is likely secreted as a homodimer. TGM4 contains an active enzyme site between aa 263‑353, and shows a C-terminal Ig-like domain (aa 587‑684). The molecule has a requirement for divalent calcium. There are two potential splice variants. One shows a 45 aa insertion after Leu8, while another shows a 12 aa substitution for aa 1‑80. Human full‑length TGM4 shares only 54% aa identity with mouse TGM4.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array AF5760

• Transglutaminase 4/TGM4 Antibodies
• Transglutaminase 4/TGM4 ELISA Kits
• Transglutaminase 4/TGM4 Lysate
• Transglutaminase 4/TGM4 Proteins
• Transglutaminase 4/TGM4 Proteins and Enzyme