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TIA1 Antibody (rTIA1/1353) [PerCP]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
rTIA1/1353
Clonality
Monoclonal
Host
Mouse
Conjugate
PerCP

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TIA1 Antibody (rTIA1/1353) [PerCP] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
Recombinant full-length human TIA1 protein
Localization
Cytoplasm.
Specificity
Within hematopoietic cell lines, the rTIA1/1353 monoclonal antibody (monoclonal antibody) reacts with about 90% of CD16+, 50 60% of CD8+, and less than 10% of CD4+ normal peripheral blood lymphocytes It reacts with almost all monocytes and granulocytes This antibody also reacts with CD4+ activated T cell clones, activated NK cell clones, and Con activated thymocytes, but not with B lymphocytes or B cell lines TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells)
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TIA1
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Alternate Names for TIA1 Antibody (rTIA1/1353) [PerCP]

  • cytotoxic granule-associated RNA-binding protein
  • nucleolysin TIA-1 isoform p40
  • p40-TIA-1 (containing p15-TIA-1)
  • p40-TIA-1
  • RNA-binding protein TIA-1
  • T-cell-restricted intracellular antigen-1
  • TIA1 cytotoxic granule-associated RNA binding protein
  • TIA1 cytotoxic granule-associated RNA-binding protein
  • TIA-1

Background

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TIA1