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Thrombomodulin/BDCA-3 Antibody (6C8.2F9) [Janelia Fluor® 635]

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Summary
Product Discontinued
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    • Catalog Number
      NBP2-42213JF635
    • Availability
      Product Discontinued

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Thrombomodulin/BDCA-3 Antibody (6C8.2F9) [Janelia Fluor® 635] Summary

Immunogen
Partial recombinant human CD141 protein (between amino acids 200-400) [UniProt P07204].
Isotype
IgG1 Lambda
Clonality
Monoclonal
Host
Mouse
Gene
THBD
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Thrombomodulin/BDCA-3 Antibody (6C8.2F9) [Janelia Fluor® 635]

  • BDCA3
  • BDCA-3
  • CD141 antigen
  • CD141
  • Fetomodulin
  • THBD
  • THRM
  • Thrombomodulin
  • TM

Background

CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Blogs on Thrombomodulin/BDCA-3.

Check out the latest blog posts on Thrombomodulin/BDCA-3.
Thrombomodulin - A multifunctional protein with roles in inflammation and coagulation
Thrombomodulin, also known as BDCA-3, is a glycosylated transmembrane protein present on the surface of vascular endothelial cells. Thrombomodulin is a high-affinity receptor for thrombin, a key protein in the coagulation cascade. Formation of the...  Read full blog post.
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Bioinformatics

Gene Symbol THBD