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Thrombomodulin/BDCA-3 Antibody (501733) [DyLight 405]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, CyTOF-ready, ELISA, ELISA(Cap), ELISA(Det)
Clone
501733
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 405

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB3947U-100UG
Alexa Fluor 405
FAB3947V-100UG
Alexa Fluor 488
FAB3947G-100UG
Alexa Fluor 532
FAB3947X
Alexa Fluor 594
FAB3947T-100UG
Alexa Fluor 647
FAB3947R-100UG
Alexa Fluor 700
FAB3947N-100UG
Alexa Fluor 750
FAB3947S-100UG
Allophycocyanin
FAB3947A
Allophycocyanin/Cy7
FAB3947APCCY7
Biotin
FAB3947B
CoraFluor 1
FAB3947CL1
DyLight 350
FAB3947D
DyLight 488
FAB3947K
DyLight 550
FAB3947L
DyLight 594
FAB3947M
DyLight 650
FAB3947W
DyLight 680
FAB3947Y
DyLight 755
FAB3947Z
HRP
FAB3947H
Janelia Fluor 525
FAB3947JF525
Janelia Fluor 549
FAB3947I
Janelia Fluor 585
FAB3947JF585
Janelia Fluor 635
FAB3947JF635
Janelia Fluor 646
FAB3947J
Janelia Fluor 669
FAB3947JF669
PE/Atto594
FAB3947PEATT594
PE/Cy5.5
FAB3947PECY55
PE/Cy7
FAB3947PECY7
PerCP
FAB3947C
Unconjugated
MAB3947-100
mFluor Violet 450 SE
FAB3947MFV450
mFluor Violet 500 SE
FAB3947MFV500
mFluor Violet 610 SE
FAB3947MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB3947-100
Carrier Free
MAB3947-100
Carrier Free
FAB3947A
Carrier Free
MAB3947-SP
Carrier Free
FAB3947R-100UG
Carrier Free
FAB3947N-100UG
Carrier Free
FAB3947G-100UG
Carrier Free
FAB3947V-100UG
Carrier Free
FAB3947U-100UG
Carrier Free
FAB3947T-100UG
Carrier Free
FAB3947S-100UG
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Thrombomodulin/BDCA-3 Antibody (501733) [DyLight 405] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Thrombomodulin/BDCA-3
Ala19-Ser515
Accession # P07204(Val473)
Specificity
Detects human Thrombomodulin/BDCA-3 in ELISAs.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
THBD
Purity
Protein A or G purified from hybridoma culture supernatant
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • ELISA Capture (Matched Antibody Pair)
  • ELISA Detection (Matched Antibody Pair)
  • ELISA Standard (Matched Pair)
  • Flow Cytometry
  • Immunohistochemistry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Thrombomodulin/BDCA-3 Antibody (501733) [DyLight 405]

  • BDCA3
  • BDCA-3
  • CD141 antigen
  • CD141
  • Fetomodulin
  • THBD
  • THRM
  • Thrombomodulin
  • TM

Background

CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Thrombomodulin - A multifunctional protein with roles in inflammation and coagulation
Thrombomodulin, also known as BDCA-3, is a glycosylated transmembrane protein present on the surface of vascular endothelial cells. Thrombomodulin is a high-affinity receptor for thrombin, a key protein in the coagulation cascade. Formation of the...  Read full blog post.
mFluor Violet Conjugated Antibodies

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Bioinformatics

Gene Symbol THBD