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TFF1/pS2 Antibody (SPM313) [Alexa Fluor® 594]

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Product Details

Summary
Reactivity Hu, Pm-CmSpecies Glossary
Applications IHC
Clone
SPM313
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 594

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-48009AF350
Alexa Fluor 405
NBP2-48009AF405
Alexa Fluor 488
NBP2-48009AF488
Alexa Fluor 532
NBP2-48009AF532
Alexa Fluor 647
NBP2-48009AF647
Alexa Fluor 700
NBP2-48009AF700
Alexa Fluor 750
NBP2-48009AF750
Biotin
NBP2-48009B
DyLight 350
NBP2-48009UV
DyLight 405
NBP2-48009V
DyLight 488
NBP2-48009G
DyLight 550
NBP2-48009R
DyLight 594
NBP2-48009DL594
DyLight 650
NBP2-48009C
DyLight 680
NBP2-48009FR
DyLight 755
NBP2-48009IR
FITC
NBP2-48009F
HRP
NBP2-48009H
Janelia Fluor 549
NBP2-48009JF549
Janelia Fluor 646
NBP2-48009JF646
Unconjugated
NBP2-44998-0.1mg
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-44998-0.1mg
Azide and BSA Free
NBP2-48009-0.1mg
IHC-Prediluted
NBP2-48460
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TFF1/pS2 Antibody (SPM313) [Alexa Fluor® 594] Summary

Immunogen
A synthetic peptide (around aa 57-84) of human TFF1/pS2 polypeptide (exact sequence is proprietary) (Uniprot: P04155)
Epitope
aa57-84
Localization
Cytoplasmic
Specificity
It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TFF1
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TFF1/pS2 Antibody (SPM313) [Alexa Fluor® 594]

  • BCEI
  • BCEIbreast cancer, estrogen-inducible sequence expressed in
  • Breast cancer estrogen-inducible protein
  • breast cancer estrogen-inducible sequence
  • D21S21
  • gastrointestinal trefoil protein pS2
  • hP1.A
  • HPS2
  • PNR-2
  • Polypeptide P1.A
  • Protein pS2
  • PS2
  • TFF1
  • trefoil factor 1
  • trefoil factor, BCE1, human pS2 induced by estrogen from human breast cancercell line M10HP1.A

Background

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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TFF1/pS2 Antibody
(SPM313) [Alexa Fluor ...
NBP2-48009AF594
TFF1/pS2 Antibody (SPM313) [Alexa Fluor® 594]
Species: Hu, Pm-Cm
Applications: IHC

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Bioinformatics

Gene Symbol TFF1