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Serpin A1/alpha 1-Antitrypsin Antibody (AAT/1378) [Janelia Fluor® 585]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clone
AAT/1378
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 585

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-11618AF350
Alexa Fluor 405
NBP3-11618AF405
Alexa Fluor 488
NBP3-11618AF488
Alexa Fluor 532
NBP3-11618AF532
Alexa Fluor 594
NBP3-11618AF594
Alexa Fluor 647
NBP3-11618AF647
Alexa Fluor 700
NBP3-11618AF700
Alexa Fluor 750
NBP3-11618AF750
Allophycocyanin
NBP3-11618APC
Biotin
NBP3-11618B
CoraFluor 1
NBP3-11618CL1
DyLight 350
NBP3-11618UV
DyLight 405
NBP3-11618V
DyLight 488
NBP3-11618G
DyLight 550
NBP3-11618R
DyLight 594
NBP3-11618DL594
DyLight 650
NBP3-11618C
DyLight 680
NBP3-11618FR
DyLight 755
NBP3-11618IR
FITC
NBP3-11618F
HRP
NBP3-11618H
Janelia Fluor 525
NBP3-11618JF525
Janelia Fluor 549
NBP3-11618JF549
Janelia Fluor 635
NBP3-11618JF635
Janelia Fluor 646
NBP3-11618JF646
Janelia Fluor 669
NBP3-11618JF669
PE
NBP3-11618PE
PerCP
NBP3-11618PCP
Unconjugated
NBP2-48476-0.1mg
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-48476-0.1mg
Azide and BSA Free
NBP3-11618
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Serpin A1/alpha 1-Antitrypsin Antibody (AAT/1378) [Janelia Fluor® 585] Summary

Immunogen
Recombinant human Serpin A1/alpha 1-Antitrypsin protein fragment (Uniprot: P01009)
Localization
Cytoplasmic
Marker
Hepatocellular & Histiocytic Marker
Specificity
It recognizes a protein of 54kDa, which is identified antitrypsin (AAT). The immunohistochemical staining of AAT is useful in identification of benign and malignant hepatic tumors and yolk sac carcinomas. Positive staining for AAT is also used in detection of benign and malignant lesions of histiocytic nature. This antibody is may also useful tool in the screening of patients with cryptogenic cirrhosis or other forms of liver disease with fibrosis of uncertain origin.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
SERPINA1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Serpin A1/alpha 1-Antitrypsin Antibody (AAT/1378) [Janelia Fluor® 585]

  • A1A
  • A1AT
  • AATMGC23330
  • alpha 1-Antitrypsin
  • alpha 1-Proteinase Inhibitor
  • Alpha-1 protease inhibitor
  • Alpha-1-antiproteinase
  • alpha-1-antitrypsin
  • antitrypsin), member 1
  • member 1
  • PIMGC9222
  • serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase
  • serine (or cysteine) proteinase inhibitor, clade A, member 1
  • Serpin A1
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)

Background

Alpha 1 Antitrypsin, also known as SERPINA1, is a plasma protein synthesised in the liver. It consists of a single polypeptide chain and has a molecular weight of 52 kDa. A serine protease inhibitor, its primary function is the protection of lung tissue from the action of neutrophil elastase. The average level of alpha 1 Antitrypsin in plasma is 1.3 g/l.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SERPINA1