SEC23A Antibody

Coatomer proteins are involved in regulating transport between the endoplasmic reticulum (ER) and the Golgi complex and in intra-Golgi transport. There exist two Coatomer-Protein mechanisms (COPI and COPII) and although they have mechanistic parallels, they are molecularly distinct. The COPI coat is comprised of seven subunits (alpha-, beta-, beta'-, gamma-, delta-, epsilon-, and zeta-COP) in a complex called coatomer. Assembly of the coatomer (COPI) onto non-clathrin coated vesicles is regulated by ADP-ribosylation factor (ARF). Vesicle formation, budding, fusion, and disassembly is dependent on GDP-GTP exchange, COPI, and ARF. COPI has been shown to facilitate retrograde intracellular transport from the ER to the Golgi complex. By contrast, COPII facilitates anterograde transport between these subcellular organelles. COPII has been shown to be independently and selectively recruited to the ER relative to COPI subunits.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: ICC/IF, IF/IHC.

Showing Publications 1 - 3 of 3.

Publications using NBP2-34842	Applications	Species
Lee H, Jiang Y, Chang H, Cheng I Foot-and-mouth disease virus 3A hijacks Sar1 and Sec12 for ER remodeling in a COPII-independent manner Viruses 2022-04-23 [PMID: 35458569]
Bogdanov V, Soltisz AM, Moise N Et al. Distributed synthesis of sarcolemmal and sarcoplasmic reticulum membrane proteins in cardiac myocytes Basic research in cardiology 2021-10-28 [PMID: 34713358] (IF/IHC, ICC/IF, Mouse)	IF/IHC, ICC/IF	Mouse
Guo C, Chi Z, Jiang D et al. Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages. Immunity. 2018-10-18 [PMID: 30366764] (Mouse)		Mouse

Array NBP2-34842

• SEC23A Antibodies
• SEC23A Lysate