RPS19 Antibody (3C6)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 5 of 5.

Publications using H00006223-M01	Applications	Species
Aspesi A, Pavesi E, Robotti E et al. Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond-Blackfan Anemia. Gene. 2014-05-15 [PMID: 24835311]
Singh SA, Goldberg TA, Henson AL et al. p53-Independent Cell Cycle and Erythroid Differentiation Defects in Murine Embryonic Stem Cells Haploinsufficient for Diamond Blackfan Anemia-Proteins: RPS19 versus RPL5. PLoS One. 2014-02-18 [PMID: 24558476]
Caterino M, Corbo C, Imperlini E et al. Differential proteomic analysis in human cells subjected to ribosomal stress. Proteomics. 2013-02-15 [PMID: 23412928]
Sezgin G, Henson AL, Nihrane A et al. Impaired growth, hematopoietic colony formation, and ribosome maturation in human cells depleted of Shwachman-Diamond syndrome protein SBDS. Pediatr Blood Cancer. 2013-02-01 [PMID: 22997148] (WB, Human)	WB	Human
Rey MA, Duffy SP, Brown JK et al. Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis. Haematologica. 2008-11-01 [PMID: 18815190]

Array H00006223-M01

• RPS19 Antibodies
• RPS19 Lysate
• RPS19 Proteins