RPA2 Antibody (12F3.3)

Replication protein A (RPA) is a single-stranded DNA binding protein. Human RPA is a heterotrimeric protein containing subunits of 70, 32, and 14 kDa. This protein complex is highly conserved in eukaryotes and is essential in DNA replication, homologous recombination, and nucleotide excision repair. RPA has been shown to be a target for DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia-mutated gene (ATM), and a cyclin dependent protein kinase. The middle subunit, RPA-32, is phosphorylated during the S-phase of the cell cycle, in response to DNA damage and during apoptotsis of Jurkat T- lymphocytes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Chemotaxis.

Showing Publications 1 - 3 of 3.

Publications using NB100-158	Applications	Species
Sundaravinayagam Devakumar, Rahjouei Ali, Andreani Matteo et al. 53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function. Cell Reports 2019-08-06 [PMID: 31390554] (Chemotaxis, Mouse)	Chemotaxis	Mouse
Salas TR, Petruseva I, Lavrik O et al. Evidence for direct contact between the RPA3 subunit of the human replication protein A single-stred DNA. Nucleic Acids Res 37(1):38-46. 2009-01-01 [PMID: 19010961]
Yoshihara T, Ishida M, Kinomura A et al. XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells. EMBO J 2004-02-01 [PMID: 14749735] (Human)		Human

Array NB100-158

• RPA2 Antibodies
• RPA2 Lysate
• RPA2 Proteins