Recombinant Mouse EMMPRIN/CD147 His-tag Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Extracellular matrix metalloproteinase (MMP) inducer (EMMPRIN), also known as basigin, membrane glycoprotein gp42, and CD147, is a 45-55 kDa, N-glycosylated type 1 transmembrane molecule which is categorized as a member of immunoglobulin superfamily (1-4). Mouse EMMPRIN is 389 amino acid (aa) in length and contains 21 aa signal sequence, 304 aa extracellular domain (ECD), 24 aa transmembrane (TM) segment, and 40 aa cytoplasmic tail (CT). The ECD contains one C2‑type and one V-type Ig-like domain. EMMPRIN is expressed in areas of tissue remodeling, including endometrium, placenta, skin, and regions undergoing angiogenesis (1, 2, 5, 6). It is also expressed on cells with high metabolic activity, such as lymphoblasts, macrophages and particularly tumor cells (2, 7). On such cells, EMMPRIN is often co-expressed with the amino acid transporter CD98h (8). EMMPRIN also interacts with caveolin1 (via its C2-type domain), and this reduces the level of EMMPRIN glycosylation and subsequent EMMPRIN multimerization and activity (9). In addition, EMMMPRIN is reported to complex with both annexin II and beta 1 integrins alpha 3 and alpha 6, an interaction that contributes to tumor growth and metastasis (10-12). Finally, the soluble calcium binding protein S100A9 has now been identified as a ligand for EMMPRIN, and it may mediate many of the tumorigenic activities attributed to EMMPRIN (13). EMMPRIN's TM sequence contains a charged aa (Glu), and a Pro important for intracellular interactions with cyclophilins (CyP) (3, 14, 15). CyPA (cyclosporin A receptor) and CyP60 interactions with the TM segment promote leukocyte inflammatory chemotaxis and surface expression of EMMPRIN, respectively (14, 15). An active 22 kDa fragment can be shed from tumor cells by MT1-MMP (1). Tumor cells can also release active, full length EMMPRIN in microvesicles (16, 17). EMMPRIN Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8 and SLC16A11 to the plasma membrane. It also plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. EMMPRIN stimulates adjacent fibroblasts to produce matrix metallo-proteinases (MMPS) and seems to be a receptor for oligomannosidic glycans. In vitro, it promotes outgrowth of astrocytic processes (18, 19). Finally, EMMPRIN is known to induce urokinase type plasminogen activator (uPA), VEGF, hyaluronan and multiple MMPs (1, 2, 6).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Cell Culture.

Showing Publication 1 - 1 of 1.

Publication using 772-EM	Applications	Species
G Feigelman, E Simanovich, P Brockmeyer, MA Rahat Knocking-Down CD147/EMMPRIN Expression in CT26 Colon Carcinoma Forces the Cells into Cellular and Angiogenic Dormancy That Can Be Reversed by Interactions with Macrophages Biomedicines, 2023-03-02;11(3):. 2023-03-02 [PMID: 36979746] (Cell Culture, Mouse)	Cell Culture	Mouse

Array 772-EM

• EMMPRIN/CD147 Antibodies
• EMMPRIN/CD147 Antibody Pair
• EMMPRIN/CD147 ELISA Kit
• EMMPRIN/CD147 Lysates
• EMMPRIN/CD147 Proteins
• EMMPRIN/CD147 ELISAs
• EMMPRIN/CD147 Proteins and Enzymes