Pygopus-2 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Pygopus-2 is a 41 kDa nuclear protein that functions as a transcriptional co-activator in the Wnt signaling pathway. Human Pygopus-2 is synthesized as a 406 amino acid (aa) residue protein that has the conserved N-terminal homology domain (NHD) and the C-terminal PHD (Plant homeodomain) zinc finger. The PHD zinc finger binds Legless/Bcl9, which in turn binds beta -Catenin, which recruits TCF/LEF DNA binding proteins. Formulation of the quaternary complex is required for the activation of Wnt-responsive genes. Over the region used for immunization, human Pygopus-2 shares 95% amino acid sequence identity with the mouse protein.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using AF3616	Applications	Species
Z-M Zhang, J-F Wu, Q-C Luo, Q-F Liu, Q-W Wu, G-D Ye et al. Pygo2 activates MDR1 expression and mediates chemoresistance in breast cancer via the Wnt/ beta -catenin pathway Oncogene 2016-09-08 [PMID: 26876203]

Array AF3616

• Pygopus-2 Antibodies
• Pygopus-2 Proteins