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MTGR1 Antibody - BSA Free

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Immunocytochemistry/ Immunofluorescence: MTGR1 Antibody [NBP2-56057] - Staining of human cell line U-2 OS shows localization to nuclear speckles.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free

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Catalog# & Formulation Size Price

MTGR1 Antibody - BSA Free Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: HRLCGQNLHGQSPHGQGRPLLPVGRGSSARSADCSVPSPALDKTSATTSRSSTPASVTAIDTNG
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CBFA2T2
Purity
Affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
Application Notes
Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
Control Peptide
MTGR1 Recombinant Protein Antigen (NBP2-56057PEP)

Reactivity Notes

Mouse 89%, Rat 88%

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for MTGR1 Antibody - BSA Free

  • core-binding factor, runt domain, alpha subunit 2; translocated to, 2
  • EHTDKFZp313F2116
  • ETO homolog on chromosome 20
  • ETO homologous on chromosome 20
  • MTG8-like protein
  • MTG8-related protein 1
  • MTGR1p85
  • myeloid translocation gene-related protein 1
  • Myeloid translocation-related protein 1
  • protein CBFA2T2
  • ZMYND3

Background

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CBFA2T2