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Lamin A + C Antibody (4C4) [Janelia Fluor® 646]

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Product Details

Summary
Reactivity Hu, Mu, Rt, PmSpecies Glossary
Applications WB, ICC/IF
Clone
4C4
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 646

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-25151AF350
Alexa Fluor 405
NBP2-25151AF405
Alexa Fluor 488
NBP2-25151AF488
Alexa Fluor 532
NBP2-25151AF532
Alexa Fluor 594
NBP2-25151AF594
Alexa Fluor 647
NBP2-25151AF647
Alexa Fluor 700
NBP2-25151AF700
Alexa Fluor 750
NBP2-25151AF750
Biotin
NBP2-25151B
CoraFluor 1
NBP2-25151CL1
DyLight 350
NBP2-25151UV
DyLight 405
NBP2-25151V
DyLight 488
NBP2-25151G
DyLight 550
NBP2-25151R
DyLight 594
NBP2-25151DL594
DyLight 650
NBP2-25151C
DyLight 680
NBP2-25151FR
DyLight 755
NBP2-25151IR
FITC
NBP2-25151F
HRP
NBP2-25151H
Janelia Fluor 525
NBP2-25151JF525
Janelia Fluor 549
NBP2-25151JF549
Janelia Fluor 585
NBP2-25151JF585
Janelia Fluor 635
NBP2-25151JF635
Janelia Fluor 669
NBP2-25151JF669
Unconjugated
NBP2-25151
mFluor Violet 450 SE
NBP2-25151MFV450
mFluor Violet 500 SE
NBP2-25151MFV500
mFluor Violet 610 SE
NBP2-25151MFV610
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Lamin A + C Antibody (4C4) [Janelia Fluor® 646] Summary

Immunogen
Full length recombinant human lamin A expressed in and purified from E. coli. [UniProt# P02545]
Localization
Nucleus. Nucleus envelope.
Marker
Nuclear Envelope Marker
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
LMNA
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Monkey and Mouse reactivity reported in scientific literature (PMID:31871052).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Lamin A + C Antibody (4C4) [Janelia Fluor® 646]

  • CDCD1
  • CDDC
  • CMD1A
  • CMT2B1
  • dilated 1A (autosomal dominant)
  • EMD2
  • FPLD
  • HGPSFPL
  • lamin A/C
  • lamin A/C-like 1
  • lamin-A/C
  • LDP1
  • LFP
  • LGMD1B
  • limb girdle muscular dystrophy 1B (autosomal dominant)
  • LMN1IDC
  • LMNC
  • LMNL1
  • prelamin-A/C
  • PRO1,70 kDa lamin
  • progeria 1 (Hutchinson-Gilford type)
  • renal carcinoma antigen NY-REN-32

Background

Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Lamin A + C
Antibody (4C4) [Janel ...
NBP2-25151JF646
Lamin A + C Antibody (4C4) [Janelia Fluor® 646]
Species: Hu, Mu, Rt, Pm
Applications: WB, ICC/IF

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol LMNA