Integrin alpha L/CD11a Antibody (MEM-25) - BSA Free

CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation; binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 10 of 10.

Publications using NB500-328	Applications	Species
Aubert M, Yoon M, Sloan DD et al. The virological synapse facilitates herpes simplex virus entry into T cells J Virol 2009-06-01 [PMID: 19339346] Details: This citation used the FITC version of this antibody.
Wang JH, Kwas C, Wu L. Intercellular adhesion molecule 1 (ICAM-1), but not ICAM-2 and -3, is important for dendritic cell-mediated human immunodeficiency virus type 1 transmission J Virol 2009-05-01 [PMID: 19211748] Details: This citation used the FITC version of this antibody.
Ottonello L, Epstein AL, Mancini M et al. Monoclonal LYM-1 antibody-dependent cytolysis by human neutrophils exposed to GM-CSF: auto-regulation of target cell attack by cathepsin G J Leukoc Biol 2004-01-01 [PMID: 14525961] Details: This citation used the FITC version of this antibody.
Mathison RD, Befus AD, Davison JS, Woodman RC. Modulation of neutrophil function by the tripeptide feG BMC Immunol 2003-03-01 [PMID: 12659660] Details: This citation used the FITC version of this antibody.
Hajishengallis G, Martin M, Sojar HT et al. Dependence of bacterial protein adhesins on toll-like receptors for proinflammatory cytokine induction Clin Diagn Lab Immunol 2002-03-01 [PMID: 11874886] Details: This citation used the FITC version of this antibody.
Garnotel R, Rittie L, Poitevin S et al. Human blood monocytes interact with type I collagen through alpha x beta 2 integrin (CD11c-CD18, gp150-95) J Immunol 2000-06-01 [PMID: 10820275] Details: This citation used the FITC version of this antibody.
Simon SI, Cherapanov V, Nadra I et al. Signaling functions of L-selectin in neutrophils: alterations in the cytoskeleton and colocalization with CD18 J Immunol 1999-09-01 [PMID: 10453036] Details: This citation used the FITC version of this antibody.
Ottonello L, Epstein AL, Dapino P et al. Monoclonal Lym-1 antibody-dependent cytolysis by neutrophils exposed to granulocyte-macrophage colony-stimulating factor: intervention of FcgammaRII (CD32), CD11b-CD18 integrins, and CD66b glycoproteins Blood [PMID: 10233903] Details: Used the FITC form of this antibody.
Bazil V, Stefanova I, Hilgert I et al. Monoclonal antibodies against human leucocyte antigens IV Antibodies against subunits of the LFA-1 (CD11a/CD18) leucocyte-adhesion glycoprotein Folia Biol (Praha) 1990-01-01 [PMID: 1971601] Details: This citation used the FITC version of this antibody.
Wang JH, Kwas C, Wu L. Intercellular adhesion molecule 1 (ICAM-1), but not ICAM-2 and -3, is important for dendritic cell-mediated human immunodeficiency virus type 1 transmission J Virol Details: This publication used the FITC conjugated form of this antibody (Cat# NB500-636).

Array NB500-328

• Integrin alpha L/CD11a Antibodies
• Integrin alpha L/CD11a ELISA Kits
• Integrin alpha L/CD11a Lysate