IL-23A/IL-23 P19 Antibody (727753) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1‑5). The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Human and mouse p19 share 70% aa sequence identity. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naïve and memory human T cells, the effects of IL-23 is restricted to memory T cells. In mouse, IL-23 but not IL-12, has also been shown to induce memory T cells to secret IL-17, a potent proinflammatory cytokine. IL-12 and IL-23 can induce IL-12 production from mouse splenic DC of both the CD8^- and CD8⁺ subtypes, however only IL-23 can act directly on CD8⁺ DC to mediate immunogenic presentation of poorly immunogenic tumor/self peptide.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Flow Cytometry, Functional Assay.

Showing Publications 1 - 4 of 4.

Publications using MAB17161	Applications	Species
Xiuxing Liu, Jianjie Lv, Huishi Wang, Yingfeng Zheng, Wenru Su Functional analysis of human circulating immune cells based on high-dimensional mass cytometry STAR Protocols 6/1/2022 [PMID: 35434658]
M Ogishi, R Yang, C Aytekin, D Langlais, M Bourgey, T Khan, FA Ali, M Rahman, OM Delmonte, M Chrabieh, P Zhang, C Gruber, SJ Pelham, AN Spaan, J Rosain, WT Lei, S Drutman, MD Hellmann, MK Callahan, M Adamow, P Wong, JD Wolchok, G Rao, CS Ma, Y Nakajima, T Yaguchi, K Chamoto, SC Williams, JF Emile, F Rozenberg, MS Glickman, F Rapaport, G Kerner, G Allington, I Tezcan, D Cagdas, FO Hosnut, F Dogu, A Ikinciogul, VK Rao, L Kainulaine, V Béziat, J Bustamante, S Vilarinho, RP Lifton, B Boisson, L Abel, D Bogunovic, N Marr, LD Notarangel, SG Tangye, T Honjo, P Gros, S Boisson-Du, JL Casanova Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child Nature Medicine, 2021-06-28;0(0):. 2021-06-28 [PMID: 34183838] (Flow Cytometry, Human)	Flow Cytometry	Human
Duluc D, Joo H, Ni L, Yin W, Upchurch K, Li D, Xue Y, Klucar P, Zurawski S, Zurawski G, Oh S Induction and activation of human Th17 by targeting antigens to dendritic cells via dectin-1. J Immunol, 2014-05-16;192(12):5776-88. 2014-05-16 [PMID: 24835401] (Flow Cytometry, Functional Assay, Human)	Flow Cytometry, Functional Assay	Human
Nieminen J, Sipponen T, Farkkila M, Vaarala O Monocyte-derived dendritic cells from Crohn's disease patients exhibit decreased ability to activate T helper type 17 responses in memory cells. Clin Exp Immunol, 2014-07-01;177(1):190-202. 2014-07-01 [PMID: 24635023] (Flow Cytometry, Human)	Flow Cytometry	Human

Array MAB17161

• IL-23A/IL-23 P19 Antibodies
• IL-23A/IL-23 P19 Lysate
• IL-23A/IL-23 P19 Proteins
• IL-23A/IL-23 P19 ELISAs
• IL-23A/IL-23 P19 Proteins and Enzymes