IL-15 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 15 (IL-15) is a widely expressed 14 kDa cytokine that is structurally and functionally related to IL-2 (1-3). Mature mouse IL-15 shares 70% and 96% amino acid sequence identity with human and rat IL-15, respectively. Alternate splicing generates isoforms of IL-15 with either a long or short signal peptide (LSP or SSP), and the SSP isoform is retained intracellularly (4). IL-15 binds with high affinity to IL-15 R alpha (5). It binds with lower affinity to a complex of IL-2 R beta and the common gamma chain ( gamma c) which are also subunits of the IL-2 receptor complex (1, 6). IL-15 associates with IL-15 R alpha in the endoplasmic reticulum, and this complex is expressed on the cell surface (7, 8). The dominant mechanism of IL-15 action is known as transpresentation in which IL-15 and IL-15 R alpha are coordinately expressed on the surface of one cell and interact with complexes of IL-2 R beta / gamma c on adjacent cells (9). This enables cells to respond to IL-15 even if they do not express IL-15 R alpha (8, 10). Soluble IL-15-binding forms of IL-15 R alpha can be generated by proteolytic shedding or alternate splicing (11-13). These molecules retain the ability to bind tightly to IL-15 and can either inhibit or augment IL-15 function (5, 12, 13). Consistent with its shared use of IL-2 receptor subunits, IL-15 induces IL-2-like effects in lymphocyte development and homeostasis (3). It is particularly important for the maintenance and activation of NK cells and CD8⁺ memory T cells (3). IL-15 also exerts pleiotropic effects on other hematopoietic cells and non-immune cells (2). Ligation of membrane-associated IL-15/IL-15 R alpha complexes induces reverse signaling that promotes cellular adhesion, tyrosine phosphorylation of intracellular proteins, and cytokine secretion by the IL-15/IL-15 R alpha expressing cells (14, 15).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 6 applications: ELISA Development, ICC, IHC, IHC-Fr, Neutralization, Western Blot.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using AF447	Applications	Species
Huang, T;Chen, X;He, J;Zheng, P;Luo, Y;Wu, A;Yan, H;Yu, B;Chen, D;Huang, Z; Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel eLife 2024-06-24 [PMID: 38913071] (Western Blot, Mouse)	Western Blot	Mouse
M Yu, H Pan, N Che, L Li, C Wang, Y Wang, G Ma, M Qian, J Liu, M Zheng, H Xie, L Ling, Y Zhao, X Guan, Q Ding, W Zhou, S Wang Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells Cell. Mol. Immunol., 2020-05-08;0(0):. 2020-05-08 [PMID: 32385362] (Neutralization, Mouse)	Neutralization	Mouse
A Suhail, ZA Rizvi, P Mujagond, SA Ali, P Gaur, M Singh, V Ahuja, A Awasthi, CV Srikanth DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells Cell Rep, 2019-12-10;29(11):3522-3538.e7. 2019-12-10 [PMID: 31825833] (Neutralization, Mouse)	Neutralization	Mouse
A Yoshikawa, K Bi, DB Keskin, G Zhang, B Reinhold, EL Reinherz TCR-pMHC encounter differentially regulates transcriptomes of(-) tissue-resident CD8 T cells Eur. J. Immunol., 2017-09-29;0(0):. 2017-09-29 [PMID: 28872670] (IHC-Fr, Mouse)	IHC-Fr	Mouse
W Rabacal, SK Pabbisetty, KL Hoek, D Cendron, Y Guo, D Maseda, E Sebzda Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival Proc Natl Acad Sci USA, 2016-04-25;0(0):. 2016-04-25 [PMID: 27114551] (IHC-Fr, Mouse)	IHC-Fr	Mouse
A Kupz, U Zedler, M Stäber, C Perdomo, A Dorhoi, R Brosch, SH Kaufmann ESAT-6-dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo J Clin Invest, 2016-04-25;0(0):. 2016-04-25 [PMID: 27111234] (Neutralization, Mouse)	Neutralization	Mouse
Pennati A, Deng J, Galipeau J Maltose-binding protein fusion allows for high level bacterial expression and purification of bioactive mammalian cytokine derivatives. PLoS ONE, 2014-09-08;9(9):e106724. 2014-09-08 [PMID: 25198691] (Western Blot, Mouse)	Western Blot	Mouse
Ma N, Xiao H, Marrero B, Xing C, Wang X, Zheng M, Han G, Chen G, Hou C, Shen B, Li Y, Wang R, Jiang Z Combination of TACI-IgG and anti-IL-15 treats murine lupus by reducing mature and memory B cells. Cell Immunol, 2014-04-12;289(1):140-4. 2014-04-12 [PMID: 24791699] (Neutralization, Mouse)	Neutralization	Mouse
Jayaraman A, Jackson D, Message S, Pearson R, Aniscenko J, Caramori G, Mallia P, Papi A, Shamji B, Edwards M, Westwick J, Hansel T, Stanciu L, Johnston S, Bartlett N IL-15 complexes induce NK- and T-cell responses independent of type I IFN signaling during rhinovirus infection. Mucosal Immunol, 2014-01-29;7(5):1151-64. 2014-01-29 [PMID: 24472849] (IHC, Mouse)	IHC	Mouse
Gomez-Nicola D, Valle-Argos B, Nieto-Sampedro M Blockade of IL-15 activity inhibits microglial activation through the NFkappaB, p38, and ERK1/2 pathways, reducing cytokine and chemokine release. Glia, 2010-02-01;58(3):264-76. 2010-02-01 [PMID: 19610094] (ICC, Neutralization, Mouse)	ICC, Neutralization	Mouse
Mortier E, Woo T, Advincula R, Gozalo S, Ma A IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J. Exp. Med., 2008-05-05;205(5):1213-25. 2008-05-05 [PMID: 18458113] (ELISA Development, Mouse)	ELISA Development	Mouse
Rafei M, Wu JH, Annabi B, Lejeune L, Francois M, Galipeau J A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex. Blood, 2006-11-02;109(5):2234-42. 2006-11-02 [PMID: 17082320] (Western Blot, Mouse)	Western Blot	Mouse
Show All 12 Publications. Collapse Publications.

Array AF447

• IL-15 Antibodies
• IL-15 Antibody Pair
• IL-15 ELISA Kits
• IL-15 Lysate
• IL-15 Proteins
• IL-15 ELISAs
• IL-15 Proteins and Enzymes