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Granzyme A Antibody (356412)

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Granzyme A was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) using 8 µg/mL Mouse Anti-Human Granzyme A Monoclonal Antibody (Catalog # MAB29051) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained (green). View our protocol for Fluorescent ICC Staining of Non-adherent Cells.
Granzyme A was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) using 8 µg/mL Mouse Anti-Human Granzyme A Monoclonal Antibody (Catalog # MAB29051) for 3 hours at room temperature. Cells ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IP, CyTOF-ready, Flow, ICC/IF
Clone
356412
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
IC29051U-100UG
Alexa Fluor 405
IC29051V-100UG
Alexa Fluor 488
IC29051G-100UG
Alexa Fluor 532
FAB29051X
Alexa Fluor 594
IC29051T-100UG
Alexa Fluor 647
IC29051R-100UG
Alexa Fluor 700
IC29051N-100UG
Alexa Fluor 750
IC29051S-100UG
Allophycocyanin
FAB29051A
Biotin
FAB29051B
CoraFluor 1
FAB29051CL1
DyLight 350
FAB29051D
DyLight 405
FAB29051E
DyLight 488
FAB29051K
DyLight 550
FAB29051L
DyLight 594
FAB29051M
DyLight 650
FAB29051W
DyLight 680
FAB29051Y
DyLight 755
FAB29051Z
HRP
FAB29051H
Janelia Fluor 525
FAB29051JF525
Janelia Fluor 549
FAB29051I
Janelia Fluor 585
FAB29051JF585
Janelia Fluor 635
FAB29051JF635
Janelia Fluor 646
FAB29051J
Janelia Fluor 669
FAB29051JF669
PE
FAB29051P
PerCP
FAB29051C
mFluor Violet 450 SE
FAB29051MFV450
mFluor Violet 500 SE
FAB29051MFV500
mFluor Violet 610 SE
FAB29051MFV610
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB29051-SP
Carrier Free
IC29051V-100UG
Carrier Free
IC29051U-100UG
Carrier Free
IC29051T-100UG
Carrier Free
IC29051S-100UG
Carrier Free
IC29051R-100UG
Carrier Free
IC29051N-100UG
Carrier Free
IC29051G-100UG
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Granzyme A Antibody (356412) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Granzyme A
Cys26-Val262
Accession # P12544
Specificity
Detects human Granzyme A in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Granzyme B, C, D, G, or H is observed.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
GZMA
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Immunocytochemistry 8-25 ug/mL
  • Immunoprecipitation 25 ug/mL
  • Intracellular Staining by Flow Cytometry 2.5 ug/10^6 cells

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Granzyme A Antibody (356412)

  • CTL Tryptase
  • CTLA3
  • CTLA3Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factorserine protease)
  • Cytotoxic T-lymphocyte proteinase 1
  • EC 3.4.21
  • Fragmentin-1
  • granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
  • Granzyme A
  • Granzyme-1
  • GZMA
  • H factor
  • Hanukkah factor
  • HF
  • HFSP
  • HFSPEC 3.4.21.78

Background

Granzyme A is a member of the granzyme family of the serine proteases found specifically in the cytotoxic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme A is the most abundant protease in CTL and NK cells. It induces caspase‑independent cell death when introduced into target cells by perforin (1). Human granzyme A is synthesized as a precursor (262 residues) with a signal peptide (residues 1‑26), a propeptide (residues 27‑28) and a mature chain (residues 29‑262) (2). The purified recombinant human Granzyme A consists of residues 26 to 262. After being activated by lysyl endopeptidase, it cleaves a thioester substrate.

  1. Lieberman, J. and Z. Fan (2003) Curr. Opin. Immunol. 15:553.
  2. Gershenfeld, H.K. et al. (1988) Proc. Natl. Acad. Sci. USA 85:1184.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GZMA
Uniprot