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GABA-AR alpha 3 Antibody

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Immunohistochemistry-Paraffin: GABA-AR alpha 3 Antibody [NBP3-14326] - Immunohistochemistry of formalin-fixed, paraffin-embedded human brain, globus pallidus, after heat-induced antigen retrieval.

Product Details

Summary
Reactivity Hu, Mu, Pm, Pm, RbSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

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GABA-AR alpha 3 Antibody Summary

Description
Product can be stored undiluted at 4C for up to 1 month.
Immunogen
Synthetic 15 amino acid peptide from C-Terminus of human GABA-AR alpha 3.
Epitope
C-Terminus
Specificity
Human GABA-AR alpha 3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Mouse (93%), Rabbit (100%), Primate (100%), Monkey (100%). Backed by our 100% Guarantee.
Clonality
Polyclonal
Host
Rabbit
Gene
GABRA3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
.

Reactivity Notes

Expected reactivity based on percent sequence identity: Rat, Canine, Equine (87%), Bovine, Bat (80%)

Packaging, Storage & Formulations

Storage
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GABA-AR alpha 3 Antibody

  • GABA A R alpha 3
  • GABA(A) receptor subunit alpha-3
  • GABAARa3
  • GABRA3
  • gamma-aminobutyric acid (GABA) A receptor, alpha 3
  • gamma-aminobutyric acid receptor subunit alpha-3
  • gamma-animobutyric acid (GABA) A receptor, alpha 3
  • MGC33793

Background

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; P ltl et al., 2003).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol GABRA3