FAT1 Antibody

The Drosophila FAT 1 gene does not belong to the classical cadherin gene family yet encodes a transmembrane protein containing 34 cadherin repeats in association with a number of other motifs. The Drosophila FAT locus encodes a tumor suppressor gene and recessive (loss-of-function) mutations lead to hyperplastic overgrowth of the imaginal discs, indicating that contact dependent cell interactions may play an important role in regulating growth and cell adhesion. This excessive cell proliferation occurs while maintaining normal epithelial organization and differentiation potential. Expressed in many epithelial and some endothelial and smooth muscle cells. Humans contain many homologs of FAT including FAT1, or hFAT

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: FLOW, IF/IHC, WB.

Showing Publications 1 - 7 of 7.

Publications using NBP1-84565	Applications	Species
Kim J, Park J, Shin S et al. Neo-Fs Index: A Novel Immunohistochemical Biomarker Panel Predicts Survival and Response to Anti-Angiogenetic Agents in Clear Cell Renal Cell Carcinoma Cancers 2021-03-10 [PMID: 33801954] (IF/IHC, Human)	IF/IHC	Human
Lin DC, Meng X, Hazawa M et al. The genomic landscape of nasopharyngeal carcinoma. Nat Genet 2014-08-01 [PMID: 24952746]
Weekes MP, Tomasec P, Huttlin EL et al. Quantitative Temporal Viromics: An Approach to Investigate Host-Pathogen Interaction. Cell 2014 Jun 5 [PMID: 24906157] (FLOW, WB, Human)	FLOW, WB	Human
Lin DC, Hao JJ, Nagata Y et al. Genomic and molecular characterization of esophageal squamous cell carcinoma. Nat Genet 2014-05-01 [PMID: 24686850]
Wojtalewicz N, Sadeqzadeh E, Weiss JV et al. A Soluble Form of the Giant Cadherin Fat1 Is Released from Pancreatic Cancer Cells by ADAM10 Mediated Ectodomain Shedding. PLoS One 2014 [PMID: 24625754] (WB)	WB
Caruso N, Herberth B, Bartoli M et al. Deregulation of the Protocadherin Gene FAT1 Alters Muscle Shapes: Implications for the Pathogenesis of Facioscapulohumeral Dystrophy. PLoS Genet 2013-06-01 [PMID: 23785297]
Morris LG, Kaufman AM, Gong Y et al. Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nat Genet 2013-03-01 [PMID: 23354438]

Array NBP1-84565

• FAT1 Antibodies
• FAT1 Proteins