EPCR Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Protein C is a vitamin K-dependent serine protease that plays a major role in blood coagulation. Binding of Protein C to EPCR (CD201) leads to the proteolytic activation of PAR1 (protease-activated receptor 1) on endothelial cells and subsequent up-regulation of Protein C-induced genes. EPCR is a type I transmembrane glycoprotein in the CD1/MHC family. It is expressed most strongly in the endothelial cells of arteries and veins in heart and lung. Membrane bound EPCR is released by metalloproteolytic cleavage to generate the soluble receptor. The extracellular domain of human and mouse EPCR shares approximately 61% amino acid sequence homology.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 7 applications: Flow Cytometry, ICC, IHC, IHC-Fr, IHC-P, Immunohistochemistry, Western Blot.

Showing Publications 1 - 8 of 8.

Publications using AF2749	Applications	Species
Xue, M;Jackson, CJ;Lin, H;Zhao, R;Liang, HPH;Weiler, H;Griffin, JH;March, L; Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model International journal of molecular sciences 2024-01-19 [PMID: 38279255] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
MM Castillo, Q Yang, AS Sigala, DT McKinney, M Zhan, KL Chen, JA Jarzembows, R Sood The endothelial protein C receptor plays an essential role in the maintenance of pregnancy Sci Adv, 2020-11-06;6(45):. 2020-11-06 [PMID: 33158859] (IHC, Mouse)	IHC	Mouse
DL Coutu, KD Kokkaliari, L Kunz, T Schroeder Multicolor quantitative confocal imaging cytometry Nat. Methods, 2017-11-13;15(1):39-46. 2017-11-13 [PMID: 29320487] (IHC, Mouse)	IHC	Mouse
Greineder , Colin F, Chacko , Ann-Mari, Zaytsev , Sergei, Zern , Blaine J, Carnemolla , Ronald, Hood , Elizabet, Han , Jingyan, Ding , Bi-Sen, Esmon , Charles, Muzykantov , Vladimir Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor. PLoS ONE, 2013-11-14;8(11):e80110. 2013-11-14 [PMID: 24244621] (ICC, Mouse)	ICC	Mouse
N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs. Biochem Biophys Res Commun, 2012-10-22;428(3):354-9. 2012-10-22 [PMID: 23092738] (Flow Cytometry, IHC-Fr, Mouse)	Flow Cytometry, IHC-Fr	Mouse
Xue M, Dervish S, Harrison LC, Fulcher G, Jackson CJ Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice. J. Biol. Chem., 2012-03-23;287(20):16356-64. 2012-03-23 [PMID: 22447930] (IHC-P, Mouse)	IHC-P	Mouse
Disse J, Petersen HH, Larsen KS The Endothelial Protein C Receptor Supports Tissue Factor Ternary Coagulation Initiation Complex Signaling through Protease-activated Receptors. J. Biol. Chem., 2010-12-13;286(7):5756-67. 2010-12-13 [PMID: 21149441] (Western Blot, Mouse)	Western Blot	Mouse
Finigan JH, Boueiz A, Wilkinson E, Damico R, Skirball J, Pae HH, Damarla M, Hasan E, Pearse DB, Reddy SP, Grigoryev DN, Cheadle C, Esmon CT, Garcia JG, Hassoun PM Activated protein C protects against ventilator-induced pulmonary capillary leak. Am. J. Physiol. Lung Cell Mol. Physiol., 2009-04-10;296(6):L1002-11. 2009-04-10 [PMID: 19363121] (Western Blot, Mouse)	Western Blot	Mouse

Array AF2749

• EPCR Antibodies
• EPCR Lysate
• EPCR Proteins
• EPCR Proteins and Enzymes
• EPCR ELISA