eIF4G1 [p Ser1231] Antibody

eIF4G1 (eukaryotic translation Initiation Factor 4 Gamma 1) is a component of the protein complex eIF-4 which is involved in the recognition of the mRNA cap ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of mRNA to the ribosome. eIF4G plays a critical role in protein expression and is at the center of a complex regulatory network. Together with the cap-binding protein eIF4E, it recruits the small ribosomal subunit to the 5'-end of mRNA and promotes the assembly of a functional translation initiation complex which scans along the mRNA to the translation start codon. Human eIF4G contains three consecutive HEAT domains, as well as long unstructured regions involved in multiple protein-protein interactions. The interactions of eIF4G1 with other factors are largely unknown.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NBP1-04965	Applications	Species
Dobrikov MI, Shveygert M, Brown M, Gromeier M. Mitotic phosphorylation of eukaryotic initiation factor (eIF) 4G1 at Ser1232 by Cdk1:Cyclin B inhibits eIF4A helicase complex binding with RNA. Mol Cell Biol. 2013-11-18 [PMID: 24248602] (WB, Human)	WB	Human
Dobrikov MI, Dobrikova EY, Gromeier M et al. Dynamic regulation of the translation initiation helicase complex by mitogenic signal transduction to eIF4G Mol Cell Biol 2012-12-21 [PMID: 23263986] (WB, Human)	WB	Human
Dobrikov M, Dobrikova E, Shveygert M, Gromeier M. Phosphorylation of eIF4G1 by PKC{alpha} Regulates eIF4G1 Binding to Mnk1. Mol Cell Biol;31(14):2947-59. 2011-07-01 [PMID: 21576361]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB		01/11/2013	View Summary Application Western Blot

Array NBP1-04965

• eIF4G1 Antibodies
• eIF4G1 Lysate
• eIF4G1 Proteins