Recombinant Human EGF Protein

This lyophilized preparation is stable for 12 months from date of receipt at -20 to -70 degrees C, preferably desiccated. Upon reconstitution, the preparation can be stored for 1 month at 2-8 degrees C under sterile conditions, and for 3 months at -20 degrees C to -70 degrees C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Stock solutions should be aliquoted and stored at < -20 degrees C. Further dilutions should be made in appropriate buffered solutions

EGF R (ErbB1) is a receptor tyrosine kinase that is widely expressed on epithelial cells and is required for epithelial cell development and proliferation. EGF R binds the EGF family ligands: EGF, Amphiregulin, TGF-alpha, Betacellulin, Epiregulin, HB-EGF, and Epigen. Ligand binding induces EGF R homodimerization as well as heterodimerization with ErbB2, ErbB3, or ErbB4. EGF R signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. Alterations in the structure, expression, and signaling of EGF R are involved in the development and metastasis of a wide variety of cancers.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using NBP2-34952	Applications	Species
Lovric A, Rassolie A, Alam S et al. Single-cell sequencing deconvolutes cellular responses to exercise in human skeletal muscle Communications biology 2022-10-22 [PMID: 36273106]
Pan J, Sheng S, Ye L et al. Extracellular vesicles derived from glioblastoma promote proliferation and migration of neural progenitor cells via PI3K-Akt pathway Cell communication and signaling : CCS 2022-01-12 [PMID: 35022057]
Xu C, Sun W, Liu J Et al. MiR-342-3p inhibits LCSC oncogenicity and cell stemness through HDAC7/PTEN axis Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2021-11-29 [PMID: 34842937]
Freed-Pastor WA, Lambert LJ, Ely ZA Et al. The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer Cancer cell 2021-07-27 [PMID: 34358448]
Robilliard LD, Yu J, Anchan A et al. Comprehensive analysis of inhibitory checkpoint ligand expression by Glioblastoma cells Immunol Cell Biol 2020-11-20 [PMID: 33217047]
Wucheng Wang, Huanjun Chen, Lei Zhang et al. A fucoidan from Nemacystus decipiens disrupts angiogenesis through targeting bone morphogenetic protein 4. Carbohydr Polym 2016-06-25 [PMID: 27083822]
Liu, Wanjun PhD, Wang et al. CYP2J2 Overexpression Increases EETs and Protects Against HFD-Induced Atherosclerosis in ApoE−/− Mice. Journal of Cardiovascular Pharmacology 2016-06-01 [PMID: 26859195]
Yan Luan, Dafei Chai, Jianjian Peng et al. A fully human monoclonal antibody targeting PD-L1 with potent anti-tumor activity. Int Immunopharmacol 2016-02-01 [PMID: 26773772]
Jiayin Hou, Liang Liu, Qian Zhu et al. MicroRNA‐185 inhibits angiogenesis in human microvascular endothelial cells through targeting stromal interaction molecule 1. Cell Biol Int 2016-03-01 [PMID: 26694763]
Yu Ma, Fu-Chun Guo, Wei Wang et al. K-ras gene mutation as a predictor of cancer cell responsiveness to metformin. Mol Med Rep 2013-09-01 [PMID: 23877793]
Xia Chen, Fei Xiao, Ying Wang et al. Structure-activity relationship study of WSS25 derivatives with anti-angiogenesis effects. Glycoconj J 2012-08-01 [PMID: 22847113]
Yuxia Xu, Qun Dong, Hong Qiu et al. A homogalacturonan from the radix of Platycodon grandiflorum and the anti-angiogenesis activity of poly-/oligogalacturonic acids derived therefrom. Carbohydr Res 2011-09-27 [PMID: 21700274]
Xiaokun Shen, Jianping Fang, Xiaofen Lv et al. Heparin Impairs Angiogenesis through Inhibition of MicroRNA-10b. J Biol Chem 2011-07-29 [PMID: 21642433]
Yuxia Xu, Qun Dong, Hong Qiu et al. Structural Characterization of an Arabinogalactan from Platycodon grandiflorum Roots and Antiangiogenic Activity of Its Sulfated Derivative. Biomacromolecules 2010-10-11 [PMID: 20839877]
Han L, Yan L, Wang K et al. Tough, self-healable and tissue-adhesive hydrogel with tunable multifunctionality. NPG Asia Materials 2017-04-14
Hong Qiu, Bo Yang, Zhi-Chao Pei, et al. WSS25 Inhibits Growth of Xenografted Hepatocellular Cancer Cells in Nude Mice by Disrupting Angiogenesis via Blocking Bone Morphogenetic Protein (BMP)/Smad/Id1 Signaling. J Biol Chem 2010-10-15 [PMID: 20679340]
Show All 16 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	SDS-PAGE Control		01/04/2017	View Summary Application SDS-PAGE Control Comments I ranked this protein with 5 stars because the cell differentiation was successfully performed. Comments Comments SDS PAGE gel with Coomassie blue staining showing detection of Human EGF protein (NBP2-34952-100 ug ) (5 ug).

Array NBP2-34952

• EGF Antibodies
• EGF Lysate
• EGF Proteins
• EGF ELISAs
• EGF Proteins and Enzymes