Name: CXCL2/GRO beta/MIP-2/CINC-3 Antibody (40605) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB452
Price: 459 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	MuSpecies Glossary
Applications	WB, B/N, ELISA(Cap)
Clone	40605
Clonality	Monoclonal
Host	Rat
Conjugate	Unconjugated

Catalog# & Formulation	Size	Price
Carrier Free MAB452-SP

Carrier Free MAB452-500

Immunogen	E. coli-derived recombinant mouse CXCL2/GRO beta /MIP-2/CINC-3 Ala28-Asn100 Accession # P10889
Specificity	Detects mouse CXCL2 in ELISAs and Western blots. In ELISAs, does not cross-react with recombinant human (rh) CXCL2/GRO beta , rhCXCL3/GRO gamma , or recombinant mouse CXCL1/KC.
Source	N/A
Isotype	IgG2b
Clonality	Monoclonal
Host	Rat
Gene	CXCL2
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

CXCL2/GRO beta/MIP-2/CINC-3 Antibody (40605) [Unconjugated]

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CXCL2/GRO beta/MIP-2/CINC-3 Antibody (40605) [Unconjugated] Summary

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Publications for CXCL2/GRO beta/MIP-2/CINC-3 Antibody (MAB452)(53)

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Bioinformatics

Publications using MAB452	Applications	Species
Yau-tuen Chan, Hor-yue Tan, Yuanjun Lu, Cheng Zhang, Chien-shan Cheng, Junyu Wu et al. Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis Acta Pharmaceutica Sinica B 2023-04-01 [PMID: 37139434]
Y Zhang, R Sang, J Bao, Z Jiang, D Qian, Y Zhou, W Su, J Wei, L Zhao, Z Wei, Y Zhao, M Shi, G Chen Schwann cell-derived CXCL2 contributes to cancer pain by modulating macrophage infiltration in a mouse breast cancer model Brain, Behavior, and Immunity, 2023-02-06;0(0):. 2023-02-06 [PMID: 36754246] (Neutralization, Mouse)	Neutralization	Mouse
J Song, D Farris, P Ariza, S Moorjani, M Varghese, M Blin, J Chen, D Tyrrell, M Zhang, K Singer, M Salmon, DR Goldstein Age-associated adipose tissue inflammation promotes monocyte chemotaxis and enhances atherosclerosis Aging Cell, 2023-01-23;0(0):e13783. 2023-01-23 [PMID: 36683460] (Neutralization, Mouse)	Neutralization	Mouse
N Li, Q Liu, Y Han, S Pei, B Cheng, J Xu, X Miao, Q Pan, H Wang, J Guo, X Wang, G Zhang, Y Lian, W Zhang, Y Zang, M Tan, Q Li, X Wang, Y Xiao, G Hu, J Jiang, H Huang, J Qin ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression Nature Communications, 2022-11-26;13(1):7281. 2022-11-26 [PMID: 36435834] (Neutralization, Mouse)	Neutralization	Mouse
Y Yu, RR Wang, NJ Miao, JJ Tang, YW Zhang, XR Lu, PY Yan, J Wang, XM Jia PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow Nature Communications, 2022-11-11;13(1):6857. 2022-11-11 [PMID: 36369287] (IHC, Mouse)	IHC	Mouse
Li-Wen Lo, Chia-Wei Chang, Ming-Feng Chiang, I-Ying Lin, Kuo-I Lin Marginal Zone B Cells Assist With Neutrophil Accumulation to Fight Against Systemic Staphylococcus aureus Infection Frontiers in Immunology 2021-05-10 [PMID: 34040603]
Anna Barkaway, Loïc Rolas, Régis Joulia, Jennifer Bodkin, Tchern Lenn, Charlotte Owen-Woods et al. Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage Immunity 2021-07-13 [PMID: 34033752]
Germana Lentini, Agata Famà, Carmelo Biondo, Nastaran Mohammadi, Roberta Galbo, Giuseppe Mancuso et al. Neutrophils Enhance Their Own Influx to Sites of Bacterial Infection via Endosomal TLR-Dependent Cxcl2 Production The Journal of Immunology 2020-02-01 [PMID: 31852751]
Z Pang, R Raudonis, C McCormick, Z Cheng Early growth response 1 deficiency protects host against Pseudomonas aeruginosa lung infection Infect. Immun., 2019-12-17;0(0):. 2019-12-17 [PMID: 31611276] (ELISA Capture, Mouse)	ELISA Capture	Mouse
M Muccioli, H Nandigam, T Loftus, M Singh, A Venkatesh, J Wright, M Pate, K McCall, F Benencia Modulation of double-stranded RNA pattern recognition receptor signaling in ovarian cancer cells promotes inflammatory queues Oncotarget, 2018-11-30;9(94):36666-36683. 2018-11-30 [PMID: 30613350] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Tamara Girbl, Tchern Lenn, Lorena Perez, Loïc Rolas, Anna Barkaway, Aude Thiriot et al. Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis Immunity 2018-12-18 [PMID: 30446388]
A Venkatesh, H Nandigam, M Muccioli, M Singh, T Loftus, D Lewis, M Pate, F Benencia Regulation of inflammatory factors by double-stranded RNA receptors in breast cancer cells Immunobiology, 2017-11-22;0(0):. 2017-11-22 [PMID: 29331323] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Z Pang, RD Junkins, AJ MacNeil, C McCormick, Z Cheng, WM Chen, TJ Lin The calcineurin-NFAT axis contributes to host defense during Pseudomonas aeruginosa lung infection J. Leukoc. Biol., 2017-10-10;0(0):. 2017-10-10 [PMID: 29018150] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
R Lv, J Zhao, M Lei, D Xiao, Y Yu, J Xie IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3 Cell. Physiol. Biochem., 2017-08-09;42(5):1961-1972. 2017-08-09 [PMID: 28793286] (Mouse)		Mouse
Qin Chaochao, Guohua Lou, Ying Yang, Yanning Liu, Ying Hu, Zheng Min et al. Macrophage Inflammatory Protein-2 in High Mobility Group Box 1 Secretion of Macrophage Cells Exposed to Lipopolysaccharide Cellular Physiology and Biochemistry 2017-01-01 [PMID: 28662496]
P Dhar, GZ Ng, EM Dunne, P Sutton Mucin 1 protects against severe Streptococcus pneumoniae infection Virulence, 2017-07-13;0(0):0. 2017-07-13 [PMID: 28605238] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
T Ishiguro, T Fukawa, K Akaki, K Nagaoka, T Takeda, Y Iwakura, K Inaba, K Takahara Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice Eur. J. Immunol, 2017-02-22;0(0):. 2017-02-22 [PMID: 28127756] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Clara Jana-Lui Busch Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice Hepatology, 2017-02-03;0(0):. 2017-02-03 [PMID: 27981604] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Patrolling monocytes promote intravascular neutrophil activation and glomerular injury in the acutely inflamed glomerulus Proc Natl Acad Sci USA, 2016-08-15;0(0):. 2016-08-15 [PMID: 27528685] (Neutralization, Mouse)	Neutralization	Mouse
Denney L, Byrne A, Shea T, Buckley J, Pease J, Herledan G, Walker S, Gregory L, Lloyd C Pulmonary Epithelial Cell-Derived Cytokine TGF-beta1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function. Immunity, 2015-11-17;43(5):945-58. 2015-11-17 [PMID: 26588780] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Lin Y, Yet S, Hsu Y, Wang G, Hung S Mesenchymal Stem Cells Ameliorate Atherosclerotic Lesions via Restoring Endothelial Function. Stem Cells Transl Med, 2014-12-10;4(1):44-55. 2014-12-10 [PMID: 25504897] (Bioassay, Human)	Bioassay	Human
Kowalewska P, Patrick A, Fox-Robichaud A Syndecan-1 in the mouse parietal peritoneum microcirculation in inflammation. PLoS ONE, 2014-09-03;9(9):e104537. 2014-09-03 [PMID: 25184228] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Emad AlShwaimi, Ellen Berggreen, Hisako Furusho, Jonathan Caleb Rossall, Justine Dobeck, Subbiah Yoganathan et al. IL-17 Receptor A Signaling Is Protective in Infection-Stimulated Periapical Bone Destruction The Journal of Immunology 2013-08-15 [PMID: 23863904]
Raghuwanshi S, Smith N, Rivers E, Thomas A, Sutton N, Hu Y, Mukhopadhyay S, Chen X, Leung T, Richardson R G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J Immunol, 2013-04-15;190(10):5329-36. 2013-04-15 [PMID: 23589623] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Junkins R, MacNeil A, Wu Z, McCormick C, Lin T Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections. J Immunol, 2013-04-15;190(10):5178-86. 2013-04-15 [PMID: 23589609] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Roy M, Richard JF, Dumas A, Vallieres L CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis. J Neuroinflammation, 2012-01-23;9(0):18. 2012-01-23 [PMID: 22269426] (Neutralization, Mouse)	Neutralization	Mouse
Cheung R, Shen F, Phillips JH, McGeachy MJ, Cua DJ, Heyworth PG, Pierce RH Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice. J. Clin. Invest., 2011-10-17;121(11):4446-61. 2011-10-17 [PMID: 22005300] (Neutralization, Mouse)	Neutralization	Mouse
Kim J, Natarajan S, Vaickus LJ, Bouchard JC, Beal D, Cruikshank WW, Remick DG Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines. Am. J. Pathol., 2011-10-01;179(6):2730-9. 2011-10-01 [PMID: 21967814] (ELISA Development, Neutralization, Mouse)	ELISA Development, Neutralization	Mouse
Zhao C, Sardella A, Chun J, Poubelle PE, Fernandes MJ, Bourgoin SG TNF-alpha promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines. J. Lipid Res., 2011-04-26;52(7):1307-18. 2011-04-26 [PMID: 21521824] (Neutralization, Mouse)	Neutralization	Mouse
Summers SA, van der Veen BS, O'Sullivan KM Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis. Kidney Int., 2010-09-15;78(12):1263-74. 2010-09-15 [PMID: 20844472] (Neutralization, Mouse)	Neutralization	Mouse
Chou RC, Kim ND, Sadik CD Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis. Immunity, 2010-08-27;33(2):266-78. 2010-08-27 [PMID: 20727790] (IHC-P, Mouse)	IHC-P	Mouse
Massena S, Christoffersson G, Hjertstrom E, Zcharia E, Vlodavsky I, Ausmees N, Rolny C, Li JP, Phillipson M A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils. Blood, 2010-06-08;116(11):1924-31. 2010-06-08 [PMID: 20530797] (Neutralization, Mouse)	Neutralization	Mouse
Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease. J. Immunol., 2010-03-12;184(8):4159-69. 2010-03-12 [PMID: 20228193] (Neutralization, Mouse)	Neutralization	Mouse
Nold-Petry CA, Nold MF, Nielsen JW, Bustamante A, Zepp JA, Storm KA, Hong JW, Kim SH, Dinarello CA Increased cytokine production in IL-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling (SOCS). J. Biol. Chem., 2009-07-10;0(0):. 2009-07-10 [PMID: 19592492] (ELISA Development, Mouse)	ELISA Development	Mouse
Wieland CW, van der Windt GJ, Florquin S, McKenzie AN, van der Poll T ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis. Microbes Infect., 2009-03-13;11(4):524-30. 2009-03-13 [PMID: 19286469] (ELISA Development, Mouse)	ELISA Development	Mouse
Kimura K, Nagaki M, Kakimi K, Saio M, Saeki T, Okuda Y, Kuwata K, Moriwaki H Critical role of CD44 in hepatotoxin-mediated liver injury. J. Hepatol., 2008-03-11;48(6):952-61. 2008-03-11 [PMID: 18395288] (Neutralization, Mouse)	Neutralization	Mouse
Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. Immunology, 2008-04-03;125(2):272-9. 2008-04-03 [PMID: 18393969] (ELISA Development, Mouse)	ELISA Development	Mouse
De Filippo K, Henderson RB, Laschinger M, Hogg N Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways. J. Immunol., 2008-03-15;180(6):4308-15. 2008-03-15 [PMID: 18322244] (IHC-P, Neutralization, Mouse)	IHC-P, Neutralization	Mouse
Scortegagna M, Cataisson C, Martin RJ, Hicklin DJ, Schreiber RD, Yuspa SH, Arbeit JM HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling. Blood, 2008-01-16;111(7):3343-54. 2008-01-16 [PMID: 18199827] (Neutralization, Mouse)	Neutralization	Mouse
Wengner AM, Pitchford SC, Furze RC, Rankin SM The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation. Blood, 2007-10-10;111(1):42-9. 2007-10-10 [PMID: 17928531] (Neutralization, Mouse)	Neutralization	Mouse
Halder RC, Aguilera C, Maricic I, Kumar V Type II NKT cell-mediated anergy induction in type I NKT cells prevents inflammatory liver disease. J. Clin. Invest., 2007-08-01;117(8):2302-12. 2007-08-01 [PMID: 17641782] (Neutralization, Mouse)	Neutralization	Mouse
Watanabe H, Kubo M, Numata K, Takagi K, Mizuta H, Okada S, Ito T, Matsukawa A Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis. J. Immunol., 2006-12-15;177(12):8650-7. 2006-12-15 [PMID: 17142765] (ELISA Development, Mouse)	ELISA Development	Mouse
Hajjar AM, Harvey MD, Shaffer SA, Goodlett DR, Sjostedt A, Edebro H, Forsman M, Bystrom M, Pelletier M, Wilson CB, Miller SI, Skerrett SJ, Ernst RK Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors. Infect. Immun., 2006-09-18;74(12):6730-8. 2006-09-18 [PMID: 16982824] (ELISA Development, Mouse)	ELISA Development	Mouse
Ramos CD, Fernandes KS, Canetti C, Teixeira MM, Silva JS, Cunha FQ Neutrophil recruitment in immunized mice depends on MIP-2 inducing the sequential release of MIP-1alpha, TNF-alpha and LTB(4). Eur. J. Immunol., 2006-08-01;36(8):2025-34. 2006-08-01 [PMID: 16856209] (ELISA Development, Mouse)	ELISA Development	Mouse
Osuchowski MF, Welch K, Siddiqui J, Remick DG Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J. Immunol., 2006-08-01;177(3):1967-74. 2006-08-01 [PMID: 16849510] (ELISA Development, Mouse)	ELISA Development	Mouse
Gao H, Hoesel LM, Guo RF, Rancilio NJ, Sarma JV, Ward PA Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury. J. Immunol., 2006-07-01;177(1):612-20. 2006-07-01 [PMID: 16785559] (ELISA Development, Mouse)	ELISA Development	Mouse
Dajee M, Muchamuel T, Schryver B, Oo A, Alleman-Sposeto J, De Vry CG, Prasad S, Ruhrmund D, Shyamsundar R, Mutnick D, Mai K, Le T, Parham C, Zhang J, Komuves L, Colby T, Hudak S, McEvoy LM, Ehrhardt RO Blockade of experimental atopic dermatitis via topical NF-kappaB decoy oligonucleotide. J. Invest. Dermatol., 2006-04-20;126(8):1792-803. 2006-04-20 [PMID: 16628194] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noel A, Cataldo DD Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J. Immunol., 2005-08-15;175(4):2589-97. 2005-08-15 [PMID: 16081833] (ELISA Development, Mouse)	ELISA Development	Mouse
Osuchowski MF, Siddiqui J, Copeland S, Remick DG Sequential ELISA to profile multiple cytokines from small volumes. J. Immunol. Methods, 2005-07-01;302(1):172-81. 2005-07-01 [PMID: 16023134] (ELISA Development, Mouse)	ELISA Development	Mouse
Jeyaseelan S, Chu HW, Young SK, Worthen GS Transcriptional profiling of lipopolysaccharide-induced acute lung injury. Infect. Immun., 2004-12-01;72(12):7247-56. 2004-12-01 [PMID: 15557650] (ELISA Development, Mouse)	ELISA Development	Mouse
Miyamoto M, Prause O, Sjostrand M, Laan M, Lotvall J, Linden A Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways. J. Immunol., 2003-05-01;170(9):4665-72. 2003-05-01 [PMID: 12707345] (Neutralization, Mouse)	Neutralization	Mouse
Knott PG, Gater PR, Dunford PJ, Fuentes ME, Bertrand CP Rapid up-regulation of CXC chemokines in the airways after Ag-specific CD4+ T cell activation. J. Immunol., 2001-01-15;166(2):1233-40. 2001-01-15 [PMID: 11145706] (Neutralization, Mouse)	Neutralization	Mouse
Tilo Biedermann, Manfred Kneilling, Reinhard Mailhammer, Konrad Maier, Christian A. Sander, George Kollias et al. Mast Cells Control Neutrophil Recruitment during T Cell–Mediated Delayed-Type Hypersensitivity Reactions through Tumor Necrosis Factor and Macrophage Inflammatory Protein 2 J. Exp. Med 2000-11-20 [PMID: 11085746]
Show All 53 Publications. Collapse Publications.

Gene Symbol	CXCL2
Uniprot	P10889()