Claudin-1 Antibody - BSA Free

Claudin1 (CLDN1), a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Tight junctions are specialized regions of cell to cell contact consisting of networking strands that act as a molecular gasket for preventing the leakage of ions, water, etc., between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition and CLDN1 expression is often cell type and tissue dependent. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. CLDN1 and CLDN2 were found to be overexpressed in colonal cancer tissues and may be useful as tumor markers and targets for the treatment of colorectal cancer. Characterization of Claudins expression in human tumors can be an additional diagnostic tool. Recent studies show that CLDN1 has gastric tumor suppressive activity and is a direct transcriptional target of RUNX3. Along with SCARB1, LDL-R, and the tetraspanin superfamily member CD81, CLDN1 has been reported to be an entry factor for the Hepatitis C virus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Canine.

We have publications tested in 5 applications: ICC/IF, IF/IHC, IHC-P, WB, Western Blot.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NBP1-77036	Applications	Species
Enrico Gugliandolo, Gianluca Antonio Franco, Ylenia Marino, Alessio Filippo Peritore, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Roberta Fusco, Ramona D’Amico, Francesco Macrì, Rosanna Di Paola, Salvatore Cuzzocrea, Rosalia Crupi Uroprotective and pain-relieving effect of dietary supplementation with micronized palmitoyl-glucosamine and hesperidin in a chronic model of cyclophosphamide-induced cystitis Frontiers in Veterinary Science 2024-01-04 [PMID: 38249555]
Han B, Lv X, Liu G et al. Gut microbiota-related bile acid metabolism-FXR/TGR5 axis impacts the response to anti-?4?7-integrin therapy in humanized mice with colitis Gut microbes 2023-07-11 [PMID: 37431863] (WB)	WB
Ledwaba S, Costa D, Bolick D et al. Enteropathogenic Escherichia coli (EPEC) Infection Induces Diarrhea, Intestinal Damage, Metabolic Alterations and Increased Intestinal Permeability in a Murine Model bioRxiv 2020-06-13 [PMID: 33392105] (WB, Mouse)	WB	Mouse
Lv Q, Xu D, Zhang X et al. Association of Hyperuricemia With Immune Disorders and Intestinal Barrier Dysfunction Frontiers in Physiology 2020-11-27 [PMID: 33329010] (Western Blot)	Western Blot
Lee PC, Hsieh YC, Huo TI et al. Active Vitamin D3 Treatment Attenuated Bacterial Translocation via Improving Intestinal Barriers in Cirrhotic Rats Molecular nutrition & food research 2020-11-30 [PMID: 33258263] (WB, Rat)	WB	Rat
Shinde T, Perera AP, Vemuri R et al. Synbiotic supplementation with prebiotic green banana resistant starch and probiotic Bacillus coagulans spores ameliorates gut inflammation in mouse model of inflammatory bowel diseases Eur J Nutr 2020-02-19 [PMID: 32419902] (WB, Human, Canine)	WB	Human, Canine
Liu X, Zhang B, Liu H et al. Determination of the available energy values and amino acid digestibility of Flammulina velutipes stem waste and its effects on carcass trait and meat quality fed to growing-finishing pigs J Anim Sci Biotechnol 2020-05-04 [PMID: 32391146] (WB)	WB
Shi Y, Li R, Yang J et al. No tight junctions in tight junction protein-1 expressing HeLa and fibroblast cells Int J Physiol Pathophysiol Pharmacol 2020-05-19 [PMID: 32067099] (IF/IHC, IHC-P, Mouse)	IF/IHC, IHC-P	Mouse
Shinde, T;Perera, AP;Vemuri, R;Gondalia, SV;Karpe, AV;Beale, DJ;Shastri, S;Southam, B;Eri, R;Stanley, R; Synbiotic Supplementation Containing Whole Plant Sugar Cane Fibre and Probiotic Spores Potentiates Protective Synergistic Effects in Mouse Model of IBD Nutrients 2019-04-11 [PMID: 30979002]
Cheng CW, Yu JC, Hsieh YH et al. Increased Cellular Levels of MicroRNA-9 and MicroRNA-221 Correlate with Cancer Stemness and Predict Poor Outcome in Human Breast Cancer Cell. Physiol. Biochem. 2018-08-15 [PMID: 30110679] (WB, Human)	WB	Human
Bulldan A, Dietze R, Shihan M, Scheiner-Bobis G. Non-classical testosterone signaling mediated through ZIP9 stimulates claudin expression and tight junction formation in Sertoli cells. Cell. Signal. 2016-05-06 [PMID: 27164415] (ICC/IF, WB, Rat)	ICC/IF, WB	Rat
Dietze R, Shihan M, Stammler A et al. Cardiotonic steroid ouabain stimulates expression of blood-testis barrier proteins claudin-1 and -11 and formation of tight junctions in Sertoli cells Mol. Cell. Endocrinol. 2015-02-07 [PMID: 25666991] (ICC/IF, Rat)	ICC/IF	Rat
Show All 12 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	ICC	Pig	06/07/2017	View Summary Application Immunocytochemistry Sample Tested pig Sc cells Species Pig Lot N/A
Enlarge	3 reviewed by: Verified Customer	ICC	Pig	06/07/2017	View Summary Application Immunocytochemistry Sample Tested pig cultured cornea cells Species Pig Lot N/A

Array NBP1-77036

• Claudin-1 Antibodies
• Claudin-1 ELISA Kits
• Claudin-1 Lysate
• Claudin-1 Proteins