CD25/IL-2R alpha Antibody (24212) [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human CD25, also known as IL-2 receptor alpha (IL-2 R alpha ) and asTac antigen, was initially identified as a 55 kDa membrane glycoprotein that is capable of binding IL‑2. The IL-2 R alpha cDNA encodes a 272 amino acid residue precursor Type I membrane protein with a 21 residue signal peptide, a 219 residue extracellular region, a 19 residue transmembrane region and a 13 residue cytoplasmic domain. IL-2 R alpha lacks structural features characteristic of members of the cytokine receptor superfamily. By itself, IL-2 R alpha binds IL-2 with low affinity. However, when IL-2 R alpha is associated with the IL-2 receptor beta and gamma chains, a high affinity heterotrimeric receptor complex that transduces IL-2 signals is formed. Soluble forms of many cytokine receptors have been reported, and a soluble form of IL-2 R alpha (IL-2 sR alpha ) appears in serum, concomitant with its increased expression on cells. The function of the soluble IL-2 R alpha is unclear. Increased levels of IL-2 sR alpha in biological fluids reportedly correlate with increased T and B cell activation and immune system activation. Increased serum concentration of IL-2 sR alpha has been observed in patients with a variety of inflammatory conditions and in the course of some leukemias and lymphomas.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 7 of 7.

Publications using FAB1020P	Applications	Species
S Shankar, J Stolp, SC Juvet, J Beckett, PS Macklin, F Issa, J Hester, KJ Wood Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis Nature Communications, 2022-06-03;13(1):3121. 2022-06-03 [PMID: 35660734] (Flow Cytometry, Human)	Flow Cytometry	Human
I Peluso, A Raguzzini, G Catasta, V Cammisotto, A Perrone, C Tomino, E Toti, M Serafini Effects of High Consumption of Vegetables on Clinical, Immunological, and Antioxidant Markers in Subjects at Risk of Cardiovascular Diseases Oxid Med Cell Longev, 2018-10-08;2018(0):5417165. 2018-10-08 [PMID: 30402206] (Flow Cytometry, Human)	Flow Cytometry	Human
Arneja A, Johnson H, Gabrovsek L, Lauffenburger D, White F Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration. J Immunol, 2013-12-02;192(1):123-35. 2013-12-02 [PMID: 24298013] (Flow Cytometry, Human)	Flow Cytometry	Human
Giuliani M, Fleury M, Vernochet A, Ketroussi F, Clay D, Azzarone B, Lataillade JJ, Durrbach A Long-lasting inhibitory effects of fetal liver mesenchymal stem cells on T-lymphocyte proliferation. 2011-05-19;6(5):e19988. 2011-05-19 [PMID: 21625521] (Flow Cytometry, Human)	Flow Cytometry	Human
Suzuki H, Onishi H, Wada J, Yamasaki A, Tanaka H, Nakano K, Morisaki T, Katano M VEGFR2 is selectively expressed by FOXP3high CD4+ Treg. Eur. J. Immunol., 2010-01-01;40(1):197-203. 2010-01-01 [PMID: 19902430] (Flow Cytometry, Human)	Flow Cytometry	Human
Ni Z, Walcheck B Cutaneous lymphocyte-associated antigen (CLA) T cells up-regulate P-selectin ligand expression upon their activation. Clin. Immunol., 2009-08-08;133(2):257-64. 2009-08-08 [PMID: 19665434] (Flow Cytometry, Human)	Flow Cytometry	Human
Ogbomo H, Michaelis M, Kreuter J, Doerr HW, Cinatl J Histone deacetylase inhibitors suppress natural killer cell cytolytic activity. FEBS Lett., 2007-03-01;581(7):1317-22. 2007-03-01 [PMID: 17349632] (Flow Cytometry, Human)	Flow Cytometry	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	Flow	Human	01/31/2019	View Summary Application Flow Cytometry Sample Tested CD8 T lymphocytes Species Human Lot LLB0518052

Array FAB1020P

• CD25/IL-2R alpha Antibodies
• CD25/IL-2R alpha ELISA Kits
• CD25/IL-2R alpha Protein
• CD25/IL-2R alpha ELISAs
• CD25/IL-2R alpha Proteins and Enzymes