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Carboxypeptidase B2/CPB2 Antibody (OTI3D5) [Janelia Fluor® 646]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
OTI3D5
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 646

Order Details

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Carboxypeptidase B2/CPB2 Antibody (OTI3D5) [Janelia Fluor® 646] Summary

Immunogen
Recombinant protein fragment corresponding to amino acids 224-423 of human Carboxypeptidase B2/CPB2 (NP_001863) produced in E.coli.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CPB2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Carboxypeptidase B2/CPB2 Antibody (OTI3D5) [Janelia Fluor® 646]

  • carboxypeptidase B2 (plasma)
  • carboxypeptidase B2 (plasma, carboxypeptidase U)
  • Carboxypeptidase B2
  • Carboxypeptidase U
  • CPB2
  • CPU
  • CPUEC 3.4.17.20
  • EC 3.4.17
  • PCPB
  • Plasma carboxypeptidase B
  • TAFI
  • TAFIcarboxypeptidase B-like protein
  • Thrombin-activable fibrinolysis inhibitor
  • thrombin-activatable fibrinolysis inhibitor

Background

Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Available sequence data analyses indicate splice variants that encode different isoforms. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CPB2