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Aurora C Antibody (OTI2B7) [FITC]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clone
OTI2B7
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-71303AF350
Alexa Fluor 405
NBP2-71303AF405
Alexa Fluor 488
NBP2-71303AF488
Alexa Fluor 532
NBP2-71303AF532
Alexa Fluor 594
NBP2-71303AF594
Alexa Fluor 647
NBP2-71303AF647
Alexa Fluor 700
NBP2-71303AF700
Alexa Fluor 750
NBP2-71303AF750
Allophycocyanin
NBP2-71303APC
Biotin
NBP2-71303B
CoraFluor 1
NBP2-71303CL1
DyLight 350
NBP2-71303UV
DyLight 405
NBP2-71303V
DyLight 488
NBP2-71303G
DyLight 550
NBP2-71303R
DyLight 594
NBP2-71303DL594
DyLight 650
NBP2-71303C
DyLight 680
NBP2-71303FR
DyLight 755
NBP2-71303IR
HRP
NBP2-71303H
Janelia Fluor 525
NBP2-71303JF525
Janelia Fluor 585
NBP2-71303JF585
Janelia Fluor 635
NBP2-71303JF635
Janelia Fluor 669
NBP2-71303JF669
PE
NBP2-71303PE
PerCP
NBP2-71303PCP
Unconjugated
NBP1-47663
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-47663
Azide and BSA Free
NBP2-71303
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Aurora C Antibody (OTI2B7) [FITC] Summary

Immunogen
Full-length protein expressed in 293T cell transfected with human AURKC expression vector
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
AURKC
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Aurora C Antibody (OTI2B7) [FITC]

  • AIE2
  • AIE2AIK3
  • AIK3
  • AIRK3
  • ARK3
  • ARK-3
  • ARK3Serine/threonine-protein kinase aurora-C
  • AurC
  • AURKC
  • Aurora 3
  • Aurora C
  • aurora kinase CAurora/IPL1/Eg2 protein 2
  • Aurora/IPL1-related kinase 3
  • aurora-C
  • Aurora-related kinase 3
  • EC 2.7.11
  • EC 2.7.11.1
  • serine/threonine kinase 13 (aurora/IPL1-like)
  • serine/threonine-protein kinase 13
  • STK13
  • STK13ARK-3

Background

Aurora-C is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process (1). Studies show that human Aurora-C is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere protein (INCENP), which are known passenger proteins. INCENP binds and activates Aurora-C in vivo and in vitro. Aurora-C co-expressed with INCENP elicits the phosphorylation of endogenous histone H3 in mammalian cells, even though this phosphorylation is not sufficient to establish chromosome condensation in interphase cells (2). Over-expression of an inactive mutant of Aurora C impaired the localization of Aurora C to the spindle midzone resulting in multinucleation which demonstrates that Aurora C is required for cytokinesis (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Aurora C Antibody
(OTI2B7) [FITC]
NBP2-71303F
Aurora C Antibody (OTI2B7) [FITC]
Species: Hu
Applications: WB, IHC

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol AURKC