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alpha-Methylacyl-CoA Racemase/AMACR Antibody (OTI5F10) [DyLight 680]

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Product Details

Summary
Reactivity Hu, Mu, Rt, CaSpecies Glossary
Applications IHC
Clone
OTI5F10
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 680

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-71749AF350
Alexa Fluor 405
NBP2-71749AF405
Alexa Fluor 488
NBP2-71749AF488
Alexa Fluor 532
NBP2-71749AF532
Alexa Fluor 594
NBP2-71749AF594
Alexa Fluor 647
NBP2-71749AF647
Alexa Fluor 700
NBP2-71749AF700
Alexa Fluor 750
NBP2-71749AF750
Allophycocyanin
NBP2-71749APC
Biotin
NBP2-71749B
CoraFluor 1
NBP2-71749CL1
DyLight 350
NBP2-71749UV
DyLight 405
NBP2-71749V
DyLight 488
NBP2-71749G
DyLight 550
NBP2-71749R
DyLight 594
NBP2-71749DL594
DyLight 650
NBP2-71749C
DyLight 755
NBP2-71749IR
FITC
NBP2-71749F
HRP
NBP2-71749H
Janelia Fluor 525
NBP2-71749JF525
Janelia Fluor 549
NBP2-71749JF549
Janelia Fluor 585
NBP2-71749JF585
Janelia Fluor 635
NBP2-71749JF635
Janelia Fluor 646
NBP2-71749JF646
Janelia Fluor 669
NBP2-71749JF669
PE
NBP2-71749PE
PerCP
NBP2-71749PCP
Unconjugated
NBP2-45491
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-45491
Azide and BSA Free
NBP2-71749
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alpha-Methylacyl-CoA Racemase/AMACR Antibody (OTI5F10) [DyLight 680] Summary

Immunogen
Full length recombinant protein of human alpha-Methylacyl-CoA Racemase/AMACR (NP_055139) produced in HEK293T cells.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
AMACR
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for alpha-Methylacyl-CoA Racemase/AMACR Antibody (OTI5F10) [DyLight 680]

  • 2-methylacyl-CoA racemase
  • alpha-Methylacyl-CoA Racemase
  • alphaMethylacylCoARacemase
  • AMACR
  • AMACRD
  • CBAS4
  • EC 5.1.99.4
  • RACE
  • RM

Background

AMACR (alpha-methylacyl-CoA racemase) has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMACR protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. AMACR can be used as a positive marker for PIN. Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4); also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol AMACR