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Pelizaeus-merzbacher Disease: Disease Bioinformatics

Research of Pelizaeus-merzbacher Disease has been linked to Diffuse Cerebral Sclerosis Of Schilder, Leukodystrophy, Nervousness, Nystagmus, Paraplegia. The study of Pelizaeus-merzbacher Disease has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Pelizaeus-merzbacher Disease include Myelination, Pathogenesis, Cell Death, Interphase, Reflex. These pathways complement our catalog of research reagents for the study of Pelizaeus-merzbacher Disease including antibodies and ELISA kits against DM20, JIMPY, ABR, ARSA, CTSC.

Top Research Reagents

We have 1469 products for the study of Pelizaeus-merzbacher Disease that can be applied to Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

Arylsulfatase A/ARSA Antibody
NBP1-00154
Western Blot: Arylsulfatase A/ARSA Antibody [NBP1-00154] - Western blot analysis of Mouse testes lysate (A) + peptide (B) with antibody at 1 ug/mL and Rat testes lysate (C) + peptide (D) with antibody at 0.3 ug/mL, 35ug protein in RIPA buffer. Detected by chemiluminescence.Immunocytochemistry/Immunofluorescence: Arylsulfatase A/ARSA Antibody [NBP1-00154] - Immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL), showing Golgi apparatus staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL).

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

1 Publication
ABR Antibody
NBP1-30981
Western Blot: ABR Antibody [NBP1-30981] - Sample (30ug whole cell lysate) A:A431, 7.5% SDS PAGE, antibody diluted at 1:1000.Immunocytochemistry/Immunofluorescence: ABR Antibody [NBP1-30981] - A431 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: ABR protein stained by ABR antibody [C3], C-term diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 um.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF

GJC2 Antibody
NBP1-59263
Western Blot: GJC2 Antibody [NBP1-59263] - Antibody Titration: 1 ug/ml Human liver.Immunohistochemistry: GJC2 Antibody [NBP1-59263] - Formalin Fixed Paraffin Embedded Tissue: Human Adult heart Observed Staining: Membrane, some cytoplasm Primary Antibody Concentration: 1:100 Secondary Antibody: Donkey anti-Rabbit-Cy2/3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec Protocol located in Reviews and Data.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

HSP60 Antibody - BSA Free
NBP1-77397
Immunocytochemistry/Immunofluorescence: HSP60 Antibody [NBP1-77397] - HeLa cells were fixed in 4% paraformaldehyde for 10 minutes and permeabilized in 0.05% Triton X-100 in PBS for 5 minutes. The cells were incubated with HSP60 Antibody (NBP1-77397) at 1 ug/ml overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:1000 dilution for 60 minutes. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 100X objective and digitally deconvolved.Western Blot: HSP60 Antibody [NBP1-77397] - Analysis of extracts from HeLa and COS cells using NBP1-77397 Hsp60 antibody at 1:1000

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Simple Western, Flow

     4 Reviews

6 Publications
RNF6 Antibody
NBP1-80251
Western Blot: RNF6 Antibody [NBP1-80251] - Titration: 1.25ug/ml Positive Control: SP2/0 cell lysate.Immunohistochemistry-Paraffin: RNF6 Antibody [NBP1-80251] - Mouse intestine, 4-8ug/ml.

Rabbit Polyclonal
Species Mouse
Applications WB, IHC, IHC-P

Myt1 Antibody
NBP1-81021
Immunocytochemistry/Immunofluorescence: Myt1 Antibody [NBP1-81021] - Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & cytosol.Immunohistochemistry-Paraffin: Myt1 Antibody [NBP1-81021] - Staining of human cerebellum shows moderate nuclear positivity in cells in granular layer.

Rabbit Polyclonal
Species Human, Mouse
Applications ICC/IF, IHC, IHC-P

3 Publications
Myelin PLP Antibody
NBP1-87781
Immunohistochemistry-Paraffin: Myelin PLP Antibody [NBP1-87781] - Staining in human cerebral cortex and pancreas tissues using anti-PLP1 antibody. Corresponding PLP1 RNA-seq data are presented for the same tissues.Immunohistochemistry-Paraffin: Myelin PLP Antibody [NBP1-87781] - Border of a demyelinated lesion. Image submitted by a verified customer review.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-P

     1 Review

5 Publications
PKMYT1 Antibody (OTI5E1)
NBP2-02275
Western Blot: PKMYT1 Antibody (5E1) [NBP2-02275] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PKMYT1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PKMYT1.Immunocytochemistry/Immunofluorescence: PKMYT1 Antibody (OTI5E1) [NBP2-02275] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY PKMYT1.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

EMAP-II/AIMP1 Antibody
NBP2-27206
Western Blot: EMAP-II/AIMP1 Antibody [NBP2-27206] - Analysis of AIMP1 using AIMP1 antibody. Human HCT116 cell lysate in the 1) absence and 2) presence of immunizing peptide and 3) mouse RAW cell lysate probed with 2 ug/ml of AIMP1 antibody. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.Immunohistochemistry-Paraffin: EMAP-II/AIMP1 Antibody [NBP2-27206] - Staining in human pancreas tissue using AIMP1 antibody at 5 ug/ml.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

2 Publications
Cathepsin C/DPPI Antibody [Unconjugated]
AF1034
Western blot shows lysates of mouse liver tissue and mouse spleen tissue. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse Cathepsin C/DPPI Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1034) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=Western blot shows lysates of mouse lung tissue and rat lung tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Mouse Cathepsin C/DPPI Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1034) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=

Goat Polyclonal
Species Mouse, Rat
Applications WB, Simple Western, IHC

13 Publications
MBL Antibody
AF2307

Goat Polyclonal
Species Human
Applications WB, ELISA(Cap), ELISA(Det)

9 Publications
Peroxiredoxin 5 Antibody [Unconjugated]
AF5724
Western blot shows lysates of human, mouse, and rat brain tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat Peroxiredoxin 5 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5724) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=Peroxiredoxin 5 was detected in immersion fixed A549 human lung carcinoma cell line using Goat Anti-Human/Mouse/Rat Peroxiredoxin 5 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5724) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # <a class=

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC

PTHLH/PTHrP Antibody (677939) [Unconjugated]
MAB6734
PTHLH/PTHrP was detected in immersion fixed paraffin-embedded sections of human colon using Mouse Anti-Human PTHLH/PTHrP Monoclonal Antibody (Catalog # MAB6734) at 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # <a class=

Mouse Monoclonal
Species Human
Applications IHC

2 Publications
MAG/Siglec-4a
538-MG


Species Rat
Applications BA

19 Publications
MBP Antibody (12)
NB600-717
Western Blot: MBP Antibody (12) [NB600-717] - Mouse Brain Tissue lysate probed with Rat anti MBP.Immunocytochemistry/Immunofluorescence: MBP Antibody (12) [NB600-717] - Histological and mRNA analysis of the inflammatory cytokines in the vehicle- or etifoxine-treated mice at onset of clinical symptoms. At day 10 p.i., drug treated animals showed significant differences in MBP staining. Animals treated with etifoxine showed an increase in retention of percentage of MBP coverage (*p = 0.001). Image collected and cropped by CiteAb from the following publication (https://embomolmed.embopress.org/cgi/doi/10.1002/emmm.201202124), licensed under a CC-BY license.

Rat Monoclonal
Species Bovine
Applications WB, ELISA, ICC/IF

     3 Reviews

42 Publications
PMP22 Antibody (Hu1) - Azide and BSA Free
NBP2-80913
Immunohistochemistry: PMP22 Antibody (Hu1) - Azide and BSA Free [NBP2-80913] - Staining of PMP22 (brown) in dorsal root ganglion and spinal roots in 20 week fetal spinal cord preparation from rhesus monkey. Image from the standard format of this antibody.

Mouse Monoclonal
Species Human, Primate, Bovine (Negative)
Applications WB, IHC, IHC-P

MBP-1 Antibody - Azide and BSA Free
NBP3-04784
Western Blot: PRG2 Antibody [NBP3-04784] - Analysis of extracts of Mouse liver, using PRG2 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit. Exposure time: 1s.Immunocytochemistry/Immunofluorescence: PRG2 Antibody [NBP3-04784] - Immunofluorescence analysis of NIH/3T3 cells using PRG2 Rabbit pAb (NBP3-04784) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

PDXP Antibody - Azide and BSA Free
NBP2-93574
Western Blot: PDXP Antibody [NBP2-93574] - Analysis of extracts of various cell lines, using PDXP at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit . Exposure time: 10s.Immunocytochemistry/Immunofluorescence: PDXP Antibody [NBP2-93574] - Immunofluorescence analysis of L929 cells using PDXP Rabbit pAb (NBP2-93574) at dilution of 1:100. Blue: DAPI for nuclear staining.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC


Related Genes

Pelizaeus-merzbacher Disease has been researched against:

Related Pathways

Pelizaeus-merzbacher Disease has been linked to:

Related Diseases

Pelizaeus-merzbacher Disease has been studied in relation to diseases such as:

Related PTMs

Pelizaeus-merzbacher Disease has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Pelizaeus-merzbacher Disease is also known as pelizaeus-merzbacher disease, spastic paraplegia 2, hereditary x-linked recessive spastic paraplegia, cockayne-pelizaeus-merzbacher disease, pelizaeus merzbacher brain sclerosis, plp1-related disorders, spg2, pmd, x linked recessive hereditary spastic paraplegia, spastic paraplegia 2, x-linked (disorder), pelizaeus-merzbacher disease (disorder), sclerosis, brain, pelizaeus-merzbacher, anophthalmia and pulmonary hypoplasia, spastic paraplegia type 2, spastic paraplegia-2, spastic paraplegia, leukodystrophies, leukodystrophy, spg 2, sppx2, pmds, hsp2.