Skp1 Products

Description

Skp1 encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

Bioinformatics

Entrez	21402 Mouse 287280 Rat 6500 Human
Uniprot	AAH25673 Human NM_170679 Human NP_008861 Human NP_008861.2 Human P63208 Human
Product By Gene ID	6500
Alternate Names	Cyclin-A/CDK2-associated protein p19 EMC19p19skp1 MGC34403 OCP2OCP-2 OCP-IIS-phase kinase-associated protein 1A (p19A) Organ of Corti protein 2 Organ of Corti protein II p19Acyclin A/CDK2-associated p19 RNA polymerase II elongation factor-like protein OCP2 RNA polymerase II elongation factor-like protein SKP1Acyclin A/CDK2-associated protein p19 S-phase kinase-associated protein 1 TCEB1LSIII Transcription elongation factor B

Research Areas for Skp1

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Wnt Signaling Pathway