PKA C beta Products

Description

The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated Calpha, Cbeta and Cgamma, that each represent specific gene products. Calpha and Cbeta are closely related (93% amino acid sequence similarity), whereas Cgamma displays 83% and 79% similarity to Calpha and Cbeta, respectively. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus where it phosphorylates the transcription factor cAMP response element binding protein (CREB) on serine 133 which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the pol II transcription initiation complex.

Bioinformatics

Entrez	5567 Human
Uniprot	AAH16285 Human NM_002731 Human NM_002731. Human NP_997461 Human P22694 Human
Product By Gene ID	5567
Alternate Names	cAMP-dependent protein kinase catalytic beta subunit isoform 4ab cAMP-dependent protein kinase catalytic subunit beta DKFZp781I2452 EC 2.7.11 EC 2.7.11.11 MGC41879 MGC9320 PKA C-beta PKACB PKACb protein kinase A catalytic subunit beta protein kinase, cAMP-dependent, catalytic, beta

Research Areas for PKA C beta

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction
Wnt Signaling Pathway